Wearable and Flexible Ozone Generating System for Treatment of Infected Dermal Wounds

dc.contributor.authorRoth, Alexanderen
dc.contributor.authorElkashif, Ahmeden
dc.contributor.authorSelyamani, Vidhyaen
dc.contributor.authorStucky, Rachel Abigailen
dc.contributor.authorSeleem, Mohamed N.en
dc.contributor.authorZiaie, Babaken
dc.contributor.authorRahimi, Rahimen
dc.date.accessioned2020-09-21T16:11:02Zen
dc.date.available2020-09-21T16:11:02Zen
dc.date.issued2020-05-19en
dc.date.updated2020-09-21T16:10:59Zen
dc.description.abstractWound-associated infections are a significant and rising health concern throughout the world owing to aging population, prevalence of diabetes, and obesity. In addition, the rapid increase of life-threatening antibiotic resistant infections has resulted in challenging wound complications with limited choices of effective therapeutics. Recently, topical ozone therapy has shown to be a promising alternative approach for treatment of non-healing and infected wounds by providing strong antibacterial properties while stimulating the local tissue repair and regeneration. However, utilization of ozone as a treatment for infected wounds has been challenging thus far due to the need for large equipment usable only in contained, clinical settings. This work reports on the development of a portable topical ozone therapy system comprised of a flexible and disposable semipermeable dressing connected to a portable and reusable ozone-generating unit via a flexible tube. The dressing consists of a multilayered structure with gradient porosities to achieve uniform ozone distribution. The effective bactericidal properties of the ozone delivery platform were confirmed with two of the most commonly pathogenic bacteria found in wound infections, Pseudomonas aeruginosa and Staphylococcus epidermidis. Furthermore, cytotoxicity tests with human fibroblasts cells indicated no adverse effects on human cells.en
dc.description.versionPublished versionen
dc.format.extent13 page(s)en
dc.format.mediumElectronic-eCollectionen
dc.format.mimetypeapplication/pdfen
dc.identifierARTN 458 (Article number)en
dc.identifier.doihttps://doi.org/10.3389/fbioe.2020.00458en
dc.identifier.eissn2296-4185en
dc.identifier.issn2296-4185en
dc.identifier.orcidSeleem, Mohamed [0000-0003-0939-0458]en
dc.identifier.pmid32509746 (pubmed)en
dc.identifier.urihttp://hdl.handle.net/10919/100021en
dc.identifier.volume8en
dc.language.isoenen
dc.publisherFrontiersen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectBiotechnology & Applied Microbiologyen
dc.subjectozoneen
dc.subjectantibiotic resistanceen
dc.subjectwound therapyen
dc.subjectsmart patchen
dc.subjectdermal wounden
dc.subjectPSEUDOMONAS-AERUGINOSAen
dc.subjectOXYGENen
dc.subjectRESISTANTen
dc.subjectEFFICACYen
dc.subject0699 Other Biological Sciencesen
dc.subject0903 Biomedical Engineeringen
dc.subject1004 Medical Biotechnologyen
dc.titleWearable and Flexible Ozone Generating System for Treatment of Infected Dermal Woundsen
dc.title.serialFrontiers in Bioengineering and Biotechnologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherArticleen
dc.type.otherJournalen
dcterms.dateAccepted2020-04-21en
pubs.organisational-group/Virginia Tech/Veterinary Medicineen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Biomedical Sciences and Pathobiologyen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/CVM T&R Facultyen
pubs.organisational-group/Virginia Techen
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