Effect of Surface Porosity on SARS-CoV-2 Fomite Infectivity

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dc.contributor.authorHosseini, Mohsenen
dc.contributor.authorPoon, Leo L.M.en
dc.contributor.authorChin, Alex W.H.en
dc.contributor.authorDucker, William A.en
dc.date.accessioned2022-06-16T20:44:45Zen
dc.date.available2022-06-16T20:44:45Zen
dc.date.issued2022-05-23en
dc.description.abstractPrevious reports indicated the low stability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on various porous surfaces, but the role of porosity was unclear because there was no direct comparison between porous and nonporous solids of the same chemistry. Through comparing pairs of solids with very similar chemistry, we find that porosity is important: porous glass has a much lower infectivity than nonporous glass. However, porosity is not sufficient to lower infectivity; permeability, which is the ability of a liquid to move through a material, is the important parameter. We show this by comparing a pair of porous CuO coatings where the pores are accessible in one case and inaccessible in the other case. When the pores are inaccessible, the infectivity remains similar to that for nonporous solids. Thus, for both glass and CuO, it is the access to porosity that decreases the infectivity of extracted liquid droplets. Having established the importance of permeability, there is the open question of the mechanism of changing the infectivity of SARSCoV- 2. Several hypotheses are possible, such as increasing the difficulty of extracting the virus from the solid, changing the drying time, increasing the surface area of active ingredient, etc. Reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) measurements show that less viral DNA is extracted from a permeable surface, suggesting that the virus becomes trapped in the pores. Finally, we consider the effect of drying. We show that permeability and the water contact angle on the solid have effects on the drying time of a contaminated droplet, which may in turn affect infectivity.en
dc.description.sponsorshipThis work was supported by the National Science Foundation under Grant CBET-1902364, the Health and Medical Research Fund (COVID190116), and the National Institute of Allergy and Infectious Diseases (contract HHSN272201400006C).en
dc.description.versionPublished versionen
dc.format.extent9 pagesen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1021/acsomega.1c06880en
dc.identifier.urihttp://hdl.handle.net/10919/110805en
dc.identifier.volume7en
dc.language.isoenen
dc.publisherACS Publicationsen
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.titleEffect of Surface Porosity on SARS-CoV-2 Fomite Infectivityen
dc.title.serialACS Omegaen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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Destination Area: Global Systems Science (GSS)
Scholarly Works, Center for Soft Matter and Biological Physics
Scholarly Works, Chemical Engineering