Cationic Polythiophenes as Responsive DNA-Binding Polymers

TR Number
Date
2013-09-23
Journal Title
Journal ISSN
Volume Title
Publisher
The Royal Society of Chemistry
Abstract

A new water soluble cationic polythiophene derivative, poly(N,N,N-trimethyl-3-(2-(thiophen-3-yl)acetamido)propan-1-aminium iodide), was synthesized via two consecutive post-polymerization functionalizations of poly(methyl 2-(thiophen-3-yl)acetate). This conjugated polymer binds DNA at N/P = 5 and forms polyplexes at N/P = 10. Its potential use as a theranostic gene delivery vehicle is investigated here.

Description
Keywords
Cationic polythiophenes, Gene delivery vectors, Nanoparticles, Conjugated polymers
Citation
Carreon, A. C., Santos, W. L., Matson, J. B., & So, R. C. (2014). Cationic polythiophenes as responsive DNA-binding polymers. Polymer Chemistry, 5(2), 314-317. doi: 10.1039/C3PY01069D