Chemical investigation of Dicranum fulvum for anticancer activity

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dc.contributor.authorCadorette, Veronica R.en
dc.contributor.committeechairKingston, David G. I.en
dc.contributor.committeememberTaylor, Larry T.en
dc.contributor.committeememberBell, Harold M.en
dc.contributor.departmentChemistryen
dc.date.accessioned2014-03-14T21:45:17Zen
dc.date.adate2012-09-08en
dc.date.available2014-03-14T21:45:17Zen
dc.date.issued1989-08-15en
dc.date.rdate2012-09-08en
dc.date.sdate2012-09-08en
dc.description.abstractBiological screening of extracts of various bryophytes showed that the species Dicranum fulvum gave extracts with activity in both <u>in vitro</u> and <u>in vivo</u> bioassays. This plant was thus selected for extraction and fractionation, monitored by i<u>in vitro</u> bioassays. Isolation was guided by a combination of bioassay and chemical methods, and led to the isolation of three compounds, betulin, 9,l9- cyclolanostâ 23â eneâ 3,25â diol, and B-sitosterol. Purification was achieved by open column, flash column, gel filtration, thin layer chromatography, the chromatotron and crystallization. The isolated compounds were identified by comparisons of spectroscopic data with those of authentic samples and the matching of experimental and literature melting points and optical rotations.en
dc.description.degreeMaster of Scienceen
dc.format.extentvii, 67 leavesen
dc.format.mediumBTDen
dc.format.mimetypeapplication/pdfen
dc.identifier.otheretd-09082012-040648en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-09082012-040648/en
dc.identifier.urihttp://hdl.handle.net/10919/44706en
dc.language.isoenen
dc.publisherVirginia Techen
dc.relation.haspartLD5655.V855_1989.C346.pdfen
dc.relation.isformatofOCLC# 20590849en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subject.lccLD5655.V855 1989.C346en
dc.subject.lcshBryophytesen
dc.subject.lcshCancer -- Treatmenten
dc.subject.lcshMedicinal plantsen
dc.titleChemical investigation of Dicranum fulvum for anticancer activityen
dc.typeThesisen
dc.type.dcmitypeTexten
thesis.degree.disciplineChemistryen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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