Different mechanisms regulate productive herpes simplex virus 1 (HSV-1) and HSV-2 infections in adult trigeminal neurons

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dc.contributor.authorBertke, Andrea S.en
dc.contributor.authorMa, AyeAyeen
dc.contributor.authorMargolis, Mathew S.en
dc.contributor.authorMargolis, Todd P.en
dc.date.accessioned2017-02-28T23:33:51Zen
dc.date.available2017-02-28T23:33:51Zen
dc.date.issued2013-03-20en
dc.description.abstractHerpes simplex virus 1 (HSV-1) and HSV-2 establish latency in different neuronal subtypes (A5+ and KH10+) in murine trigeminal ganglia, results which correlate with restricted productive infection in these neurons in vitro. HSV-2 latency-associated transcript (LAT) contains a cis-acting regulatory element near the transcription start site that promotes productive infection in A5+ neurons and a second element in exon 1 that inhibits productive infection in KH10+ neurons. HSV-1 contains no such regulatory sequences, demonstrating different mechanisms for regulating productive HSV infection in neurons.en
dc.description.notes< AUDIENCE: International >< REFEREED: Yes >< PUBLICAVAIL: Yes >< FULL_TEXT: asbertke/intellcont/2013 Different mechanisms regulate productive HSV-1 and HSV-2 infections in adult trigeminal neurons-1.pdf >< USER_REFERENCE_CREATOR: Yes >< PUB_END: 2013-03-20 >< DTx_PUB: 20/03/2013 >en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1128/JVI.00383-13en
dc.identifier.orcidBertke, Andrea S. [0000-0002-8941-8010]en
dc.identifier.urihttp://hdl.handle.net/10919/75202en
dc.language.isoenen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.titleDifferent mechanisms regulate productive herpes simplex virus 1 (HSV-1) and HSV-2 infections in adult trigeminal neuronsen
dc.title.serialJournal of Virologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/Veterinary Medicineen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/CVM T&R Facultyen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Population Health Sciencesen

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