Non-Thermal Irreversible Electroporation (N-TIRE) and Adjuvant Fractionated Radiotherapeutic Multimodal Therapy for Intracranial Malignant Glioma in a Canine Patient

Simple item page
dc.contributor.authorGarcia, Paulo A.en
dc.contributor.authorPancotto, Theresa E.en
dc.contributor.authorRossmeisl, John H. Jr.en
dc.contributor.authorHenao-Guerrero, Nataliaen
dc.contributor.authorGustafson, N. R.en
dc.contributor.authorDaniel, Gregory B.en
dc.contributor.authorRobertson, John L.en
dc.contributor.authorEllis, Thomas L.en
dc.contributor.authorDavalos, Rafael V.en
dc.date.accessioned2016-11-14T15:44:35Zen
dc.date.available2016-11-14T15:44:35Zen
dc.date.issued2011-02-01en
dc.description.abstractNon-thermal irreversible electroporation (N-TIRE) has shown promise as an ablative therapy for a variety of soft-tissue neoplasms. Here we describe the therapeutic planning aspects and first clinical application of N-TIRE for the treatment of an inoperable, spontaneous malignant intracranial glioma in a canine patient. The N-TIRE ablation was performed safely, effectively reduced the tumor volume and associated intracranial hypertension, and provided sufficient improvement in neurological function of the patient to safely undergo adjunctive fractionated radiotherapy (RT) according to current standards of care. Complete remission was achieved based on serial magnetic resonance imaging examinations of the brain, although progressive radiation encephalopathy resulted in the death of the dog 149 days after N-TIRE therapy. The length of survival of this patient was comparable to dogs with intracranial tumors treated via standard excisional surgery and adjunctive fractionated external beam RT. Our results illustrate the potential benefits of N-TIRE for in vivo ablation of undesirable brain tissue, especially when traditional methods of cytoreductive surgery are not possible or ideal, and highlight the potential radiosensitizing effects of N-TIRE on the brain.en
dc.description.versionPublished versionen
dc.format.extent73 - 83 (11) page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.issn1533-0346en
dc.identifier.issue1en
dc.identifier.urihttp://hdl.handle.net/10919/73431en
dc.identifier.volume10en
dc.language.isoenen
dc.publisherAdenine Pressen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000286483300008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectOncologyen
dc.subjectONCOLOGYen
dc.subjectElectroporationen
dc.subjectbrain tumoren
dc.subjectbrain canceren
dc.subjectneurosurgeryen
dc.subjectdogen
dc.subjectINDUCED BRAIN-INJURYen
dc.subjectABLATIONen
dc.subjectTUMORSen
dc.subjectELECTROCHEMOTHERAPYen
dc.subjectCHEMOTHERAPYen
dc.subjectIRRADIATIONen
dc.subjectTECHNOLOGYen
dc.subjectEXPRESSIONen
dc.subjectMANAGEMENTen
dc.subjectCELLSen
dc.titleNon-Thermal Irreversible Electroporation (N-TIRE) and Adjuvant Fractionated Radiotherapeutic Multimodal Therapy for Intracranial Malignant Glioma in a Canine Patienten
dc.title.serialTechnology in Cancer Research & Treatmenten
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Engineeringen
pubs.organisational-group/Virginia Tech/Engineering/Biomedical Engineering and Mechanicsen
pubs.organisational-group/Virginia Tech/Engineering/COE T&R Facultyen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/Veterinary Medicineen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/CVM T&R Facultyen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Small Animal Clinical Sciencesen

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Non-thermal irreversible electroporation (N-TIRE) and adjuvant fractionated radiotherapeutic multimodal therapy for intracranial malignant glioma in a canine patient.pdf
Size:
2.04 MB
Format:
Adobe Portable Document Format
Description:
Publisher's Version
Download
License bundle
Now showing 1 - 1 of 1
Name:
VTUL_Distribution_License_2016_05_09.pdf
Size:
18.09 KB
Format:
Adobe Portable Document Format
Description:
Download

Collections

All Faculty Deposits
Destination Area: Adaptive Brain and Behavior (ABB)
Scholarly Works, Virginia-Maryland College of Veterinary Medicine