Central administration of dipeptides, beta-alanyl-BCAAs, induces hyperactivity in chicks

Tsuneyoshi, Yousuke; Tomonaga, Shozo; Asechi, Mari; Morishita, Koji; Denbow, D. Michael; Furuse, Mitsuhiro

Central administration of dipeptides, beta-alanyl-BCAAs, induces hyperactivity in chicks

dc.contributor.author	Tsuneyoshi, Yousuke	en
dc.contributor.author	Tomonaga, Shozo	en
dc.contributor.author	Asechi, Mari	en
dc.contributor.author	Morishita, Koji	en
dc.contributor.author	Denbow, D. Michael	en
dc.contributor.author	Furuse, Mitsuhiro	en
dc.contributor.department	Animal and Poultry Sciences	en
dc.date.accessioned	2012-08-24T12:12:24Z	en
dc.date.available	2012-08-24T12:12:24Z	en
dc.date.issued	2007-05-31	en
dc.date.updated	2012-08-24T12:12:24Z	en
dc.description.abstract	Background Carnosine (β-alanyl-L-histidine) is a putative neurotransmitter and has a possible role in neuron-glia cell interactions. Previously, we reported that carnosine induced hyperactivity in chicks when intracerebroventricularly (i.c.v.) administered. In the present study, we focused on other β-alanyl dipeptides to determine if they have novel functions. Results In Experiment 1, i.c.v. injection of β-alanyl-L-leucine, but not β-alanyl-glycine, induced hyperactivity behavior as observed with carnosine. Both carnosine and β-alanyl-L-leucine stimulated corticosterone release. Thus, dipeptides of β-alanyl-branched chain amino acids were compared in Experiment 2. The i.c.v. injection of β-alanyl-L-isoleucine caused a similar response as β-alanyl-L-leucine, but β-alanyl-L-valine was somewhat less effective than the other two dipeptides. β-Alanyl-L-leucine strongly stimulated, and the other two dipeptides tended to stimulate, corticosterone release. Conclusion These results suggest that central β-alanyl-branched chain amino acid stimulates activity in chicks through the hypothalamus-pituitary-adrenal axis. We named β-alanyl-L-leucine, β-alanyl-L-isoleucine and β-alanyl-L-valine as Excitin-1, Excitin-2 and Excitin-3, respectively.	en
dc.description.version	Published version	en
dc.format.mimetype	application/pdf	en
dc.identifier.citation	BMC Neuroscience. 2007 May 31;8(1):37	en
dc.identifier.doi	https://doi.org/10.1186/1471-2202-8-37	en
dc.identifier.uri	http://hdl.handle.net/10919/18931	en
dc.language.iso	en	en
dc.rights	Creative Commons Attribution 4.0 International	en
dc.rights.holder	Yousuke Tsuneyoshi et al.; licensee BioMed Central Ltd.	en
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	en
dc.title	Central administration of dipeptides, beta-alanyl-BCAAs, induces hyperactivity in chicks	en
dc.title.serial	BMC Neuroscience	en
dc.type	Article - Refereed	en
dc.type.dcmitype	Text	en