Protein Trafficking or Cell Signaling: A Dilemma for the Adaptor Protein TOM1

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dc.contributor.authorRoach, Tiffany G.en
dc.contributor.authorLang, Helja K. M.en
dc.contributor.authorXiong, Wenen
dc.contributor.authorRyhanen, Samppa J.en
dc.contributor.authorCapelluto, Daniel G. S.en
dc.contributor.departmentBiological Sciencesen
dc.contributor.departmentFralin Life Sciences Instituteen
dc.contributor.departmentCenter for Soft Matter and Biological Physicsen
dc.date.accessioned2021-05-11T12:12:32Zen
dc.date.available2021-05-11T12:12:32Zen
dc.date.issued2021-02-26en
dc.description.abstractLysosomal degradation of ubiquitinated transmembrane protein receptors (cargo) relies on the function of Endosomal Sorting Complex Required for Transport (ESCRT) protein complexes. The ESCRT machinery is comprised of five unique oligomeric complexes with distinct functions. Target of Myb1 (TOM1) is an ESCRT protein involved in the initial steps of endosomal cargo sorting. To exert its function, TOM1 associates with ubiquitin moieties on the cargo via its VHS and GAT domains. Several ESCRT proteins, including TOLLIP, Endofin, and Hrs, have been reported to form a complex with TOM1 at early endosomal membrane surfaces, which may potentiate the role of TOM1 in cargo sorting. More recently, it was found that TOM1 is involved in other physiological processes, including autophagy, immune responses, and neuroinflammation, which crosstalk with its endosomal cargo sorting function. Alteration of TOM1 function has emerged as a phosphoinositide-dependent survival mechanism for bacterial infections and cancer progression. Based on current knowledge of TOM1-dependent cellular processes, this review illustrates how TOM1 functions in coordination with an array of protein partners under physiological and pathological scenarios.en
dc.description.notesThe authors acknowledge support from the National Institutes of General Medical Sciences (R01GM129525) and the 4-VA Collaborative Research Program (DC). TR was supported by the Virginia Tech-Initiative for Maximizing Student Development (IMSD) pre-doctoral fellowship.en
dc.description.sponsorshipNational Institutes of General Medical SciencesUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of General Medical Sciences (NIGMS) [R01GM129525]; 4-VA Collaborative Research Program; Virginia Tech-Initiative for Maximizing Student Development (IMSD) pre-doctoral fellowshipen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3389/fcell.2021.643769en
dc.identifier.issn2296-634Xen
dc.identifier.other643769en
dc.identifier.pmid33718385en
dc.identifier.urihttp://hdl.handle.net/10919/103237en
dc.identifier.volume9en
dc.language.isoenen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectTOM1en
dc.subjectTOLen
dc.subjectendosomeen
dc.subjectESCRTen
dc.subjectTOLLIPen
dc.subjectEndofinen
dc.subjectphosphoinositidesen
dc.titleProtein Trafficking or Cell Signaling: A Dilemma for the Adaptor Protein TOM1en
dc.title.serialFrontiers in Cell and Developmental Biologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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