Comparison of assessment techniques: plasma lipid and lipoproteins related to the metabolic syndrome

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dc.contributor.authorDavy, Brenda M.en
dc.contributor.authorDavy, Kevin P.en
dc.contributor.departmentHuman Nutrition, Foods, and Exerciseen
dc.date.accessioned2017-01-08T21:25:53Zen
dc.date.available2017-01-08T21:25:53Zen
dc.date.issued2006-01-31en
dc.description.abstractBackground The purpose of this investigation was to determine the influence of analytical method on reported concentrations of plasma lipids and lipoproteins, and to determine if there are clinical implications of any potential differences on identification of the metabolic syndrome dyslipidemia, CVD risk stratification and classification of LDL subclass phenotype. Results Plasma triglyceride (TG) concentrations were 1.09 ± 0.06 and 1.17 ± 0.06 mmol/L and plasma high density lipoprotein cholesterol (HDL-C) concentrations were 1.09 ± 0.03 vs 1.19 ± 0.03 mmol/L (both p < 0.05) from 113 duplicate samples sent to two laboratories utilizing different lipid and lipoprotein analytical methods (LABS 1 and 2, respectively). Plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) concentrations were also significantly different between laboratories. Spearman rho correlations indicate excellent agreement of TG and HDL-C determined by the two laboratories (r = 0.96, TG; r = 0.91, HDL-C, both p < 0.001). Eleven vs. 14 individuals met the TG criteria and 70 vs. 48 met HDL-C metabolic syndrome criteria with LAB 1 and 2, respectively. Apoprotein B concentration (LAB 1) and LDL particle number (LAB 2) were highly correlated. (r = 0.92, P < 0.01). LAB 2 characterized more individuals as LDL pattern B phenotype, as compared to LAB 1 (30 vs. 14%, P < 0.05). Conclusion Different plasma lipid and lipoprotein analytical techniques yield results which are highly correlated, yet significantly different, which suggests a consistent measurement difference. This difference has clinical implications, in that the proportion of individuals identified as meeting the metabolic syndrome dyslipidemia criteria, "at risk" based upon apo B or LDL particle number, and the LDL pattern B phenotype will differ based upon choice of analytical method.en
dc.description.versionPublished versionen
dc.format.extent5 pagesen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationLipids in Health and Disease. 2006 Jan 31;5(1):3en
dc.identifier.doihttps://doi.org/10.1186/1476-511X-5-3en
dc.identifier.issn1476-511Xen
dc.identifier.urihttp://hdl.handle.net/10919/74017en
dc.identifier.volume5en
dc.language.isoenen
dc.publisherBiomed Centralen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000247484400001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.holderBrenda M Davy et al.; licensee BioMed Central Ltd.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectBiochemistry & Molecular Biologyen
dc.subjectNutrition & Dieteticsen
dc.subjectLOW-DENSITY LIPOPROTEINSen
dc.subjectCORONARY-HEART-DISEASEen
dc.subjectCARDIOVASCULAR-DISEASEen
dc.subjectAPOLIPOPROTEIN-Ben
dc.subjectADULTSen
dc.subjectRISKen
dc.subjectPREDICTORen
dc.subjectSIZEen
dc.titleComparison of assessment techniques: plasma lipid and lipoproteins related to the metabolic syndromeen
dc.title.serialLipids in Health And Diseaseen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciencesen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/CALS T&R Facultyen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/Human Nutrition, Foods, & Exerciseen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen

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