Comparison of linear and volumetric criteria for the determination of therapeutic response in dogs with intracranial gliomas

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dc.contributor.authorGarcia Mora, Josefa Karinaen
dc.contributor.authorRobertson, John L.en
dc.contributor.authorHsu, Fang-Chien
dc.contributor.authorShinn, Richard Levonen
dc.contributor.authorLarson, Martha M.en
dc.contributor.authorRylander, Christopher G.en
dc.contributor.authorWhitlow, Christopher T.en
dc.contributor.authorDebinski, Waldemaren
dc.contributor.authorDavalos, Rafael V.en
dc.contributor.authorDaniel, Gregory B.en
dc.contributor.authorRossmeisl, John H.en
dc.date.accessioned2023-11-20T19:52:38Zen
dc.date.available2023-11-20T19:52:38Zen
dc.date.issued2022-05en
dc.date.updated2023-11-20T16:26:23Zen
dc.description.abstractBackground: Brain tumor therapeutic responses can be quantified from magnetic resonance images (MRI) using 1- (1D) and 2-dimensional (2D) linear and volumetric methods, but few studies in dogs compare these techniques. Hypotheses: Linear methods will be obtained faster, but have less agreement than volumetric measurements. Therapeutic response agreement will be highest with the total T2W tumor volumetric (TTV) method. Therapeutic response at 6-weeks will correlate with overall survival (OS). Animals: Forty-six dogs with intracranial gliomas. Methods: Prospective study. Three raters measured tumors using 1D and 2D linear, TTV, and contrast-enhancing volumetric (CEV) techniques on 143 brain MRI to determine agreement between methods, define therapeutic responses, and assess relations with OS. Results: Raters performed 1D the fastest (2.9 ± 0.57 minutes) and CEV slowest (17.8 ± 6.2 minutes). Inter- and intraobserver agreements were excellent (intraclass correlations ≥.91) across methods. Correlations between linear (1D vs 2D; ρ >.91) and volumetric (TTV vs CEV; ρ >.73) methods were stronger than linear to volumetric comparisons (ρ range,.26-.59). Incorporating clinical and imaging data resulted in fewer discordant therapeutic responses across methods. Dogs having partial tumor responses at 6 weeks had a lower death hazard than dogs with stable or progressive disease when assessed using 2D, CEV, and TTV (hazard ration 2.1; 95% confidence interval, 1.22-3.63; P =.008). Conclusions and Clinical Importance: One-dimensional, 2D, CEV, and TTV are comparable for determining therapeutic response. Given the simplicity, universal applicability, and superior performance of the TTV, we recommend its use to standardize glioma therapeutic response criteria.en
dc.description.versionPublished versionen
dc.format.extentPages 1066-1074en
dc.format.extent9 page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1111/jvim.16406en
dc.identifier.eissn1939-1676en
dc.identifier.issn0891-6640en
dc.identifier.issue3en
dc.identifier.orcidDavalos, Rafael [0000-0003-1503-9509]en
dc.identifier.orcidDaniel, Gregory [0000-0002-7313-7425]en
dc.identifier.orcidRobertson, John [0000-0002-5499-9943]en
dc.identifier.pmid35274379en
dc.identifier.urihttp://hdl.handle.net/10919/116683en
dc.identifier.volume36en
dc.language.isoenen
dc.publisherWileyen
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pubmed/35274379en
dc.rightsCreative Commons Attribution-NonCommercial 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/en
dc.subjectdogen
dc.subjectmagnetic resonance imagingen
dc.subjectneurooncologyen
dc.subjectneuroradiologyen
dc.subjectradiology and diagnostic imagingen
dc.subject3009 Veterinary Sciencesen
dc.subject30 Agricultural, Veterinary and Food Sciencesen
dc.subjectBiomedical Imagingen
dc.subjectBrain Canceren
dc.subjectCanceren
dc.subjectRare Diseasesen
dc.subjectBrain Disordersen
dc.subjectClinical Researchen
dc.subjectNeurosciencesen
dc.subject.meshAnimalsen
dc.subject.meshDogsen
dc.subject.meshGliomaen
dc.subject.meshBrain Neoplasmsen
dc.subject.meshDog Diseasesen
dc.subject.meshMagnetic Resonance Imagingen
dc.subject.meshTreatment Outcomeen
dc.subject.meshProspective Studiesen
dc.titleComparison of linear and volumetric criteria for the determination of therapeutic response in dogs with intracranial gliomasen
dc.title.serialJournal of Veterinary Internal Medicineen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherArticleen
dc.type.otherJournalen
dcterms.dateAccepted2022-03-02en
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Engineeringen
pubs.organisational-group/Virginia Tech/Veterinary Medicineen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Small Animal Clinical Sciencesen
pubs.organisational-group/Virginia Tech/Engineering/Biomedical Engineering and Mechanicsen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Engineering/COE T&R Facultyen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/CVM T&R Facultyen

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