Evaluation of a particle beam interface for LC/MS

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dc.contributor.authorCerruti, Laura F.en
dc.contributor.committeechairMcNair, Harold M.en
dc.contributor.committeememberWolfe, James F.en
dc.contributor.committeememberLong, Gary L.en
dc.contributor.departmentChemistryen
dc.date.accessioned2014-03-14T21:45:06Zen
dc.date.adate2012-09-08en
dc.date.available2014-03-14T21:45:06Zen
dc.date.issued1989-03-05en
dc.date.rdate2012-09-08en
dc.date.sdate2012-09-08en
dc.description.abstractThe performance of a Hewlett Packard Particle Beam LC/MS interface is evaluated using EPA appendix VIII and IX compounds. The behavior of these priority pollutants in the interface could determine its feasibility as a future EPA certified technique. The evaluation process consists of studies to determine minimum detectable quantities (MDQ), linear response, and band broadening contributions. The MDQ's of the analytes in electron impact and chemical ionization modes are extrapolated from experimental signal to noise data. The linearity study involves ten compounds analyzed at five different concentrations. The response factors (RF) are calculated and discussed. The study concerning the band broadening contributions of the interface involves four independent variables (helium flow, desolvation chamber temperature, source temperature, and 96 methanol) and their effects on peak width. A Box–Behnken experimental design is used and described. Response surfaces are generated from the best fit equation describing the data.en
dc.description.degreeMaster of Scienceen
dc.format.extentviii, 105 leavesen
dc.format.mediumBTDen
dc.format.mimetypeapplication/pdfen
dc.identifier.otheretd-09082012-040022en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-09082012-040022/en
dc.identifier.urihttp://hdl.handle.net/10919/44624en
dc.language.isoenen
dc.publisherVirginia Techen
dc.relation.haspartLD5655.V855_1989.C477.pdfen
dc.relation.isformatofOCLC# 20317140en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subject.lccLD5655.V855 1989.C477en
dc.subject.lcshLiquid chromatographyen
dc.subject.lcshMass spectrometryen
dc.titleEvaluation of a particle beam interface for LC/MSen
dc.typeThesisen
dc.type.dcmitypeTexten
thesis.degree.disciplineChemistryen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen
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