The effects of illness on urinary catecholamines and their metabolites in dogs

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dc.contributor.authorCameron, Kristin Nicoleen
dc.contributor.committeechairMonroe, William E.en
dc.contributor.committeememberLeib, Michael S.en
dc.contributor.committeememberMeldrum, James Blairen
dc.contributor.committeememberPanciera, David L.en
dc.contributor.departmentVeterinary Medical Sciencesen
dc.date.accessioned2017-04-04T19:50:43Zen
dc.date.adate2010-06-16en
dc.date.available2017-04-04T19:50:43Zen
dc.date.issued2010-04-23en
dc.date.rdate2016-09-27en
dc.date.sdate2010-05-01en
dc.description.abstractBackground: Urinary catecholamines and metanephrines have been proposed as a diagnostic tool for identifying canine pheochromocytomas, but the effects of critical illness on urine concentrations of catecholamines and metanephrines is currently unknown. Objectives: To examine the effects of illness on urine concentrations of catecholamines and metanephrines in dogs. Animals: Twenty-five critically ill dogs and twenty-five healthy age- and gender-matched control dogs. Methods: Prospective observational study. Urine was collected from healthy and critically ill dogs and urine concentrations of epinephrine, norepinephrine, metanephrine, and normetanephrine were measured by high-performance liquid chromatography (HPLC) with electrochemical detection. Urinary catecholamine and metanephrine:creatinine ratios were calculated and compared between groups. Results: Urinary epinephrine, norepinephrine, metanephrine, and normetanephrine:creatinine ratios were higher in critically ill dogs when compared to a healthy control population (P = 0.0009, P < 0.0001, P < 0.0001, and P < 0.0001 respectively). Conclusions and Clinical Relevance: Illness has a significant impact on urinary catecholamines and their metabolites in dogs. Further investigation of catecholamine and metanephrine concentrations in dogs with pheochromocytomas is warranted to fully evaluate this test as a diagnostic tool, however the findings of this study suggest that the results may be difficult to interpret in dogs with concurrent illness.en
dc.description.degreeMaster of Scienceen
dc.identifier.otheretd-05012010-174057en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-05012010-174057/en
dc.identifier.urihttp://hdl.handle.net/10919/76977en
dc.language.isoen_USen
dc.publisherVirginia Techen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectpheochromocytomaen
dc.subjectcritical illnessen
dc.subjectnorepinephrineen
dc.subjectdogen
dc.subjectmetanephrineen
dc.subjectcatecholaminesen
dc.subjectnormetanephrineen
dc.titleThe effects of illness on urinary catecholamines and their metabolites in dogsen
dc.typeThesisen
dc.type.dcmitypeTexten
thesis.degree.disciplineVeterinary Medical Sciencesen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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