Synthesis of Paclitaxel Analogs

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dc.contributor.authorXu, Zhibingen
dc.contributor.committeechairKingston, David G. I.en
dc.contributor.committeememberCarlier, Paul R.en
dc.contributor.committeememberSantos, Webster L.en
dc.contributor.departmentChemistryen
dc.date.accessioned2014-03-14T20:46:39Zen
dc.date.adate2010-11-29en
dc.date.available2014-03-14T20:46:39Zen
dc.date.issued2010-09-30en
dc.date.rdate2013-05-21en
dc.date.sdate2010-10-13en
dc.description.abstractPaclitaxel is one of the most successful anti-cancer drugs, particularly in the treatment of breast cancer and ovarian cancer. For the investigation of the interaction between paclitaxel and MD-2 protein, and development of new antagonists for lipopolysaccharide, several C10 A-nor-paclitaxel analogs have been synthesized and their biological activities have been evaluated. In order to reduce the myelosuppression effect of the paclitaxel, several C3â ² and C4 paclitaxel analogs have been synthesized and their biological evaluation have been studied.en
dc.description.degreeMaster of Scienceen
dc.identifier.otheretd-10132010-152742en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-10132010-152742/en
dc.identifier.urihttp://hdl.handle.net/10919/35376en
dc.publisherVirginia Techen
dc.relation.haspartFinal.pdfen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectMyelosuppressionen
dc.subjectbeta-Lactamen
dc.subjectBaccatinen
dc.subjectInflammationen
dc.subject2-Methoxyestradiolen
dc.subjectTubulinen
dc.subjectAnticancer Drugsen
dc.subjectCanceren
dc.subjectPaclitaxelen
dc.subjectAntagonistsen
dc.titleSynthesis of Paclitaxel Analogsen
dc.typeThesisen
thesis.degree.disciplineChemistryen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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