The Flavonoid Kaempferol Ameliorates Streptozotocin-Induced Diabetes by Suppressing Hepatic Glucose Production

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dc.contributor.authorAlkhalidy, Hanaen
dc.contributor.authorMoore, Willen
dc.contributor.authorWang, Yaoen
dc.contributor.authorLuo, Jingen
dc.contributor.authorMcMillan, Ryan P.en
dc.contributor.authorZhen, Weien
dc.contributor.authorZhou, Kequanen
dc.contributor.authorLiu, Dongminen
dc.contributor.departmentHuman Nutrition, Foods, and Exerciseen
dc.date.accessioned2018-09-21T16:44:14Zen
dc.date.available2018-09-21T16:44:14Zen
dc.date.issued2018-09-13en
dc.date.updated2018-09-21T07:13:50Zen
dc.description.abstractIn diabetes mellitus, the excessive rate of glucose production from the liver is considered a primary contributor for the development of hyperglycemia, in particular, fasting hyperglycemia. In this study, we investigated whether kaempferol, a flavonol present in several medicinal herbs and foods, can be used to ameliorate diabetes in an animal model of insulin deficiency and further explored the mechanism underlying the anti-diabetic effect of this flavonol. We demonstrate that oral administration of kaempferol (50 mg/kg/day) to streptozotocin-induced diabetic mice significantly improved hyperglycemia and reduced the incidence of overt diabetes from 100% to 77.8%. This outcome was accompanied by a reduction in hepatic glucose production and an increase in glucose oxidation in the muscle of the diabetic mice, whereas body weight, calorie intake, body composition, and plasma insulin and glucagon levels were not altered. Consistently, treatment with kaempferol restored hexokinase activity in the liver and skeletal muscle of diabetic mice while suppressed hepatic pyruvate carboxylase activity and gluconeogenesis. These results suggest that kaempferol may exert antidiabetic action via promoting glucose metabolism in skeletal muscle and inhibiting gluconeogenesis in the liver.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationAlkhalidy, H.; Moore, W.; Wang, Y.; Luo, J.; McMillan, R.P.; Zhen, W.; Zhou, K.; Liu, D. The Flavonoid Kaempferol Ameliorates Streptozotocin-Induced Diabetes by Suppressing Hepatic Glucose Production. Molecules 2018, 23, 2338.en
dc.identifier.doihttps://doi.org/10.3390/molecules23092338en
dc.identifier.urihttp://hdl.handle.net/10919/85078en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectkaempferolen
dc.subjectinsulin deficiencyen
dc.subjectdiabetesen
dc.subjecthepatic glucose productionen
dc.subjectgluconeogenesisen
dc.subjectpyruvate carboxylaseen
dc.titleThe Flavonoid Kaempferol Ameliorates Streptozotocin-Induced Diabetes by Suppressing Hepatic Glucose Productionen
dc.title.serialMoleculesen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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