Sibling sRNA RyfA1 Influences Shigella dysenteriae Pathogenesis
| dc.contributor.author | Fris, Megan E. | en |
| dc.contributor.author | Broach, William H. | en |
| dc.contributor.author | Klim, Sarah E. | en |
| dc.contributor.author | Coschigano, Peter W. | en |
| dc.contributor.author | Carroll, Ronan K. | en |
| dc.contributor.author | Caswell, Clayton C. | en |
| dc.contributor.author | Murphy, Erin R. | en |
| dc.date.accessioned | 2017-09-20T18:29:06Z | en |
| dc.date.available | 2017-09-20T18:29:06Z | en |
| dc.date.issued | 2017-01-26 | en |
| dc.date.updated | 2017-09-20T18:29:06Z | en |
| dc.description.abstract | Small regulatory RNAs (sRNAs) of <em>Shigella dysenteriae</em> and other pathogens are vital for the regulation of virulence-associated genes and processes. Here, we characterize RyfA1, one member of a sibling pair of sRNAs produced by <em>S. dysenteriae</em>. Unlike its nearly identical sibling molecule, RyfA2, predicted to be encoded almost exclusively by non-pathogenic species, the presence of a gene encoding RyfA1, or a RyfA1-like molecule, is strongly correlated with virulence in a variety of enteropathogens. In <em>S. dysenteriae</em>, the overproduction of RyfA1 negatively impacts the virulence-associated process of cell-to-cell spread as well as the expression of <em>ompC</em>, a gene encoding a major outer membrane protein important for the pathogenesis of Shigella. Interestingly, the production of RyfA1 is controlled by a second sRNA, here termed RyfB1, the first incidence of one regulatory small RNA controlling another in <em>S. dysenteriae</em> or any <em>Shigella</em> species. | en |
| dc.description.version | Published version | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.citation | Fris, M.E.; Broach, W.H.; Klim, S.E.; Coschigano, P.W.; Carroll, R.K.; Caswell, C.C.; Murphy, E.R. Sibling sRNA RyfA1 Influences Shigella dysenteriae Pathogenesis. Genes 2017, 8, 50. | en |
| dc.identifier.doi | https://doi.org/10.3390/genes8020050 | en |
| dc.identifier.uri | http://hdl.handle.net/10919/79306 | en |
| dc.language.iso | en | en |
| dc.publisher | MDPI | en |
| dc.rights | Creative Commons Attribution 4.0 International | en |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en |
| dc.subject | Shigella | en |
| dc.subject | sRNA | en |
| dc.subject | pathogenesis | en |
| dc.subject | riboregulators | en |
| dc.subject | sibling | en |
| dc.subject | OmpC | en |
| dc.title | Sibling sRNA RyfA1 Influences Shigella dysenteriae Pathogenesis | en |
| dc.title.serial | Genes | en |
| dc.type | Article - Refereed | en |
| dc.type.dcmitype | Text | en |