A porcine model for polymicrobial respiratory infections with swine influenza virus and Staphylococcus aureus

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dc.contributor.authorSmith, Elizabeth Allisonen
dc.contributor.committeechairMullarky, Isis K.en
dc.contributor.committeememberAkers, Robert Michaelen
dc.contributor.committeememberMcGilliard, Michael L.en
dc.contributor.committeememberSubbiah, Elankumaranen
dc.contributor.departmentDairy Scienceen
dc.date.accessioned2017-04-04T19:49:57Zen
dc.date.adate2010-11-16en
dc.date.available2017-04-04T19:49:57Zen
dc.date.issued2010-09-27en
dc.date.rdate2016-10-18en
dc.date.sdate2010-10-21en
dc.description.abstractInfluenza A virus (IAV) is a significant problem worldwide, and respiratory disease is further complicated by secondary bacterial infection. The emergence of highly pathogenic strains of IAV in conjunction with the increase of antibiotic-resistant bacteria threatens human health. A large-animal model effective for study of polymicrobial infection comparable to humans must therefore be developed. IAV has been studied extensively in small animals, including mice, rats and ferrets. However, these species frequently require IAV adaptation, reducing the capacity of these models to adequately represent human infection. Furthermore, species commonly used lack likeness to humans in both the presentation of symptoms and in lethality of infection. However, pigs are naturally susceptible to unadapted IAV and are considered to be the 'mixing vessel' for the recent pandemic IAV virus. Pigs are also susceptible to infection with Staphylococcus aureus, the most commonly isolated bacteria from IAV-infected human adults. Therefore, the use of pigs in the study of polymicrobial respiratory infections would be ideal for characterizing a host immune response comparable to humans, as well as for the development of diagnostics and therapeutics. Using this novel model, we determined that pigs are susceptible to Staphylococcus aureus, swine IAV, and polymicrobial infection. Furthermore, we showed that IAV infection predisposes pigs to Staphylococcus aureus pneumonia, and this susceptibility is dependent on day post-IAV infection.en
dc.description.degreeMaster of Scienceen
dc.identifier.otheretd-10212010-110812en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-10212010-110812/en
dc.identifier.urihttp://hdl.handle.net/10919/76882en
dc.language.isoen_USen
dc.publisherVirginia Techen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectStaphylococcus aureusen
dc.subjectpolymicrobialen
dc.subjectInfluenza A virusen
dc.subjectporcineen
dc.titleA porcine model for polymicrobial respiratory infections with swine influenza virus and Staphylococcus aureusen
dc.typeThesisen
dc.type.dcmitypeTexten
thesis.degree.disciplineDairy Scienceen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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