Development of a Hollow-Core Fiberoptic Microneedle Device for the Treatment of Invasive Bladder Cancer

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dc.contributor.authorHood, Robert L.en
dc.contributor.committeechairRylander, Christopher G.en
dc.contributor.committeememberRobertson, John L.en
dc.contributor.committeememberRylander, M. Nicholeen
dc.contributor.committeememberGrant, David C.en
dc.contributor.departmentBiomedical Engineeringen
dc.date.accessioned2017-04-04T19:49:41Zen
dc.date.adate2011-09-12en
dc.date.available2017-04-04T19:49:41Zen
dc.date.issued2011-08-11en
dc.date.rdate2016-09-30en
dc.date.sdate2011-08-19en
dc.description.abstractThe hydraulic resistance characterization manuscript chronicles the early development of the hollow-core fiberoptic microneedle device (FMD). The study determined that for straight tubing with an inner bore of 150 ?m and a length greater than 50 mm long, Poiseuille's Law was shown to be accurate within 12% of experimental data for the pressure range of 69-517 kPa. Comparison between different needle design geometries indicated that tip diameters <55 ?m cause a significant increase in hydraulic resistance. Tubing length should be kept to a minimum and tip diameter should be kept above this threshold to reduce overall hydraulic resistance. The bladder treatment study describes the fabrication and testing of the FMD for treatment of invasive urothelial cell carcinomas (UCCs). Experiments investigating the fluid dispersal of single-walled carbon nanohorns (SWNHs) in the wall of inflated, healthy ex vivo bladders demonstrated that perfusion of 2 cm° on the bladder wall's surface can be achieved with a 5 minute infusion at 50 ?L/min. Irradiation of the SWNH perfused bladder wall tissue with a free space, 1064 nm laser at an irradiance of 0.95 W/cm° for 40 seconds yielded a 480% temperature increase relative to similar irradiation of a non-infused control. Co-delivery experiments demonstrated both SWNH and light delivery though a single hollow-core fiber to heat the bladder wall 33 °C with an irradiance of 400 W/cm°, demonstrating that the FMD can be used to achieve hyperthermia-based therapeutic effects via interstitial irradiation.en
dc.description.degreeMaster of Scienceen
dc.identifier.otheretd-08192011-131101en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-08192011-131101/en
dc.identifier.urihttp://hdl.handle.net/10919/76846en
dc.language.isoen_USen
dc.publisherVirginia Techen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectBiotransporten
dc.subjectConvection-Enhanced Diffusionen
dc.subjectMicroneedleen
dc.subjectMicrofluidic Deviceen
dc.subjectCarbon Nanohornen
dc.subjectBiomimetic Infusionen
dc.titleDevelopment of a Hollow-Core Fiberoptic Microneedle Device for the Treatment of Invasive Bladder Canceren
dc.typeThesisen
dc.type.dcmitypeTexten
thesis.degree.disciplineBiomedical Engineeringen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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