Characterization of Apoptotic Cells in Equine Proximal Suspensory Desmitis

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dc.contributor.authorHewes, Christina Andreaen
dc.contributor.committeechairWhite, Nathaniel A. IIen
dc.contributor.committeememberBuechner-Maxwell, Virginia A.en
dc.contributor.committeememberRobertson, John L.en
dc.contributor.departmentBiomedical and Veterinary Sciencesen
dc.date.accessioned2014-03-14T21:38:29Zen
dc.date.adate2006-09-08en
dc.date.available2014-03-14T21:38:29Zen
dc.date.issued2006-05-30en
dc.date.rdate2008-09-08en
dc.date.sdate2006-06-14en
dc.description.abstractSuspensory desmitis is a common problem and affects a broad cross section of equine athletes in various disciplines. For this study, the proximal portion of the suspensory ligament was collected from 6 horses without suspensory ligament injury (16 ligaments) and 4 horses with degeneration of the suspensory ligament (11 ligaments). Specimens were collected immediately after euthanasia and placed in neutral-buffered 10% formalin. The tissue was fixed, sectioned, and stained with hematoxylin and eosin (H&E), Masson's trichrome, and for apoptosis by the terminal deoxynucleotidyl transferase mediated dUTP nick end labeling (TUNEL) technique. Histological changes in the abnormal ligaments included mineralization, fibroplasias, neovascularization, collagen degeneration, and significant architecture disruption in 2 ligaments. There was a trend for increased apoptosis in the injured ligaments compared to the normal ligaments.en
dc.description.degreeMaster of Scienceen
dc.identifier.otheretd-06142006-193636en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-06142006-193636/en
dc.identifier.urihttp://hdl.handle.net/10919/43303en
dc.publisherVirginia Techen
dc.relation.haspartetd.final.pdfen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectdesmitisen
dc.subjectHorsesen
dc.subjectApoptosisen
dc.subjectsuspensory ligamenten
dc.titleCharacterization of Apoptotic Cells in Equine Proximal Suspensory Desmitisen
dc.typeThesisen
thesis.degree.disciplineBiomedical and Veterinary Sciencesen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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