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Evaluation of pressor sentivity to norepinephrine infusion in dogs with iatrogenic hyperadrenocorticism

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dc.contributor.authorMartinez, Nivia Ivelliseen
dc.contributor.committeechairPanciera, David L.en
dc.contributor.committeememberWilcke, Jeffrey R.en
dc.contributor.committeememberAbbott, Jonathan A.en
dc.contributor.committeememberLeib, Michael S.en
dc.contributor.committeememberMonroe, William E.en
dc.contributor.departmentVeterinary Medical Sciencesen
dc.date.accessioned2014-03-14T20:39:57Zen
dc.date.adate2002-06-28en
dc.date.available2014-03-14T20:39:57Zen
dc.date.issued2002-04-15en
dc.date.rdate2012-10-01en
dc.date.sdate2002-06-14en
dc.description.abstractObjective: To evaluate pressor sensitivity to catecholamines in dogs after induction of iatrogenic hyperadrenocorticism (I-HAC) by serial arterial blood pressure measurements during infusions of increasing dose rates of norepinephrine. Animals: Eight dogs with I-HAC induced by administration of oral hydrocortisone at a mean dose of 3.3 mg/kg PO TID for 42-49 days and 8 control dogs which received empty gelatin capsules PO TID for 42-49 days. Procedure: Systolic, diastolic, mean blood pressure and heart rate measurements were recorded after sequential administration of increasing dose rates of norepinephrine (0.1, 0.125, 0.2, 0.3, 0.4, 0.6 and 0.8 mg/kg/min) for 10 minutes. The changes in systolic, diastolic, mean blood pressure and heart rate were compared between control dogs and dogs with I-HAC. Results: Dogs in the I-HAC group had a more pronounced pressor response to norepinephrine infusions than control dogs. The infusions were not completed in 7 of the 8 dogs in the I-HAC group versus 3 dogs in the control group due to severe elevations in systolic blood pressure. The mean change in systolic blood pressure was consistently higher in dogs in the I-HAC group. The difference was statistically significant at the 0.2 mg/kg/min norepinephrine dose rate. The mean change in heart rate was consistently lower in the I-HAC group, a difference that was significant at the 0.2 mg/kg/min norepinephrine dose rate. Conclusions and clinical relevance: Increased pressor sensitivity or decreased baroreceptor response to norepinephrine was seen in dogs with I-HAC suggesting that this mechanism is involved in the development of hypertension in canine hyperadrenocorticism.en
dc.description.degreeMaster of Scienceen
dc.identifier.otheretd-06142002-161910en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-06142002-161910/en
dc.identifier.urihttp://hdl.handle.net/10919/33566en
dc.publisherVirginia Techen
dc.relation.haspartthesis.1.final.pdfen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectnorepinephrineen
dc.subjecthypertensionen
dc.subjectcanineen
dc.subjectiatrogenic hyperadrenocorticismen
dc.titleEvaluation of pressor sentivity to norepinephrine infusion in dogs with iatrogenic hyperadrenocorticismen
dc.typeThesisen
thesis.degree.disciplineVeterinary Medical Sciencesen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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