Design of Percutaneous Dual Propeller Pump to assist Patients with Single Functional Ventricle

dc.contributor.authorJagani, Jakin Nitinkumaren
dc.contributor.committeechairUntaroiu, Alexandrinaen
dc.contributor.committeememberO'Brien, Walter F. Jr.en
dc.contributor.committeememberTarazaga, Pablo Albertoen
dc.contributor.departmentMechanical Engineeringen
dc.description.abstractVarious congenital heart defects (CHDs) are characterized by the existence of a single functional ventricle, which perfuses both the systemic and pulmonary circulation in parallel. A three-stage palliation procedure, including the final Fontan Completion, is often adopted by surgeons to treat patients with such CHDs. However, the most common outcome of this surgery, an extra-cardiac total cavopulmonary connection (TCPC), formed by suturing the inferior vena cava (IVC) and superior vena cava (SVC) to the pulmonary arteries (PAs), results in non-physiological flow conditions, systemic venous hypertension, reduced cardiac output, and pressure losses, which ultimately calls for a heart transplantation. A modest pressure rise of 5-6 mm Hg would correct the abnormal flow dynamics in these patients. To achieve this, a novel conceptual design of a percutaneous dual propeller pump inserted and mounted inside the TCPC is developed and studied. The designed blood pump is percutaneously inserted via the Femoral vein and deployed at the center of Total Cavopulmonary Connection (TCPC). The two propellers, each placed in the Superior Vena Cava (SVC) and the Inferior Vena Cava (IVC) are connected by a single shaft and motor, and thus rotate at same speed. The device is supported with the help of a self-expanding stent which would be anchored to the walls of the IVC and the SVC. An inverse design methodology implementing Blade Element Momentum theory and Goldstein's radial momentum loss theory was employed to generate the blade profiles for the studied propeller pumps. The propeller blade profiles generated from the inverse design optimization code were examined for hydraulic performance, blood flow pattern and potential for hemolysis inside the TCPC using 3-D computational fluid dynamics (CFD) analysis. The Lagrangian particle tracking approach in conjunction with a non-linear mathematical power law model was used for predicting the blood damage potential of the analysed blood pump designs by calculating the scalar shear stress history sustained by the red blood cells (RBC). The study demonstrated that the IVC and SVC propeller pumps could provide a pressure rise of 1-20 mm Hg at flow rates ranging from 0.5 to 5 lpm while rotating at speeds of 6,000-12,000 rpm. Moreover, the average Blood Damage Index (BDI), quantifying the level of blood trauma sustained by the RBCs for the analyzed propeller pump designs, was found to be around 3e-04% to 4e-04% which is within the acceptable limits for an axial flow heart assist device. Thus, such a dual propeller blood pump configuration could potentially provide assistance to Fontan patients by unloading the single functional ventricle thereby acting as a bridge to transplantation and recovery until a donor heart is available.en
dc.description.degreeMaster of Scienceen
dc.publisherVirginia Techen
dc.rightsIn Copyrighten
dc.subjectCavopulmonary Assist Deviceen
dc.subjectDual Propeller Pumpen
dc.subjectComputational fluid dynamicsen
dc.subjectBlood Damageen
dc.subjectExperimental Testingen
dc.titleDesign of Percutaneous Dual Propeller Pump to assist Patients with Single Functional Ventricleen
dc.typeThesisen Engineeringen Polytechnic Institute and State Universityen of Scienceen


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