The Effects of Anesthesia and Surgery on Thyroid Function Tests in Dogs

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dc.contributor.authorWood, Melinda Anneen
dc.contributor.committeechairPanciera, David L.en
dc.contributor.committeememberBerry, Stephanie H.en
dc.contributor.committeememberMonroe, William E.en
dc.contributor.departmentBiomedical and Veterinary Sciencesen
dc.date.accessioned2014-03-14T21:40:23Zen
dc.date.adate2007-08-16en
dc.date.available2014-03-14T21:40:23Zen
dc.date.issued2007-07-02en
dc.date.rdate2007-08-16en
dc.date.sdate2007-07-12en
dc.description.abstractBackground: Many non-thyroidal factors affect thyroid function tests. Anesthesia and surgery have been documented to affect thyroid function tests in humans but have not been extensively studied in dogs. Hypothesis: Anesthesia alone and anesthesia combined with surgery will affect thyroid function tests in dogs. Animals: 15 euthyroid mongrel dogs. Methods: Dogs were assigned to one of three groups: control, general anesthesia, and general anesthesia plus abdominal exploratory surgery. Blood samples were collected from each dog immediately prior to pre-medication, 20 minutes after pre-medication, 55 minutes after anesthesia induction, once daily for an additional 6 days, and 14 days post-procedures. Sampling was performed at identical times in the control group. Thyroxine (T4), free T4 (fT4) by equilibrium dialysis, triiodothyronine (T3), reverse T3 (rT3) and thyroid-stimulating hormone (TSH) concentrations were measured in all samples. Results: Results of all thyroid function tests were not significantly different between control and anesthesia groups. Serum T3 for the surgery group decreased significantly from baseline compared to the control and anesthesia groups at multiple times. Serum T4 and rT3 for the surgery group increased significantly from baseline compared to the control and anesthesia groups at multiple times. Serum fT4 for the surgery group increased significantly from baseline compared to the control and anesthesia groups at 48 hours only. Conclusions and Clinical Importance: Surgery has a significant effect on thyroid function tests, while the anesthetic protocol used in this study does not. Because serum T4 and fT4 concentrations increased rather than decreased, evaluating these hormones following surgery is unlikely to lead to a misdiagnosis of hypothyroidism in euthyroid dogs.en
dc.description.degreeMaster of Scienceen
dc.identifier.otheretd-07122007-163551en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-07122007-163551/en
dc.identifier.urihttp://hdl.handle.net/10919/43705en
dc.publisherVirginia Techen
dc.relation.haspartWOODTHESISFINAL.pdfen
dc.relation.haspartWOODTHESISFINAL.2.pdfen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectnon-thyroidal illnessen
dc.subjectisofluraneen
dc.subjecthypothyroidismen
dc.subjectThyroxineen
dc.titleThe Effects of Anesthesia and Surgery on Thyroid Function Tests in Dogsen
dc.typeThesisen
thesis.degree.disciplineBiomedical and Veterinary Sciencesen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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