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Herbicide injury induces DNA methylome alterations in Arabidopsis

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dc.contributor.authorKim, Gunjuneen
dc.contributor.authorClarke, Christopher R.en
dc.contributor.authorLarose, Haileyen
dc.contributor.authorTran, Hong T.en
dc.contributor.authorHaak, David C.en
dc.contributor.authorZhang, Liqingen
dc.contributor.authorAskew, Shawn D.en
dc.contributor.authorBarney, Jacoben
dc.contributor.authorWestwood, James H.en
dc.date.accessioned2022-01-13T18:30:18Zen
dc.date.available2022-01-13T18:30:18Zen
dc.date.issued2017-07en
dc.date.updated2022-01-13T18:30:16Zen
dc.description.abstractThe emergence of herbicide-resistant weeds is a major threat facing modern agriculture. Over 470 weedy-plant populations have developed resistance to herbicides. Traditional evolutionary mechanisms are not always sufficient to explain the rapidity with which certain weed populations adapt in response to herbicide exposure. Stress-induced epigenetic changes, such as alterations in DNA methylation, are potential additional adaptive mechanisms for herbicide resistance. We performed methylC sequencing of Arabidopsis thaliana leaves that developed after either mock treatment or two different sub-lethal doses of the herbicide glyphosate, the most-used herbicide in the history of agriculture. The herbicide injury resulted in 9,205 differentially methylated regions (DMRs) across the genome. In total, 5,914 of these DMRs were induced in a dose-dependent manner, wherein the methylation levels were positively correlated to the severity of the herbicide injury, suggesting that plants can modulate the magnitude of methylation changes based on the severity of the stress. Of the 3,680 genes associated with glyphosateinduced DMRs, only 7% were also implicated in methylation changes following biotic or salinity stress. These results demonstrate that plants respond to herbicide stress through changes in methylation patterns that are, in general, dose-sensitive and, at least partially, stress-specific.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.orcidBarney, Jacob [0000-0003-2949-5003]en
dc.identifier.orcidWestwood, James [0000-0001-5127-7294]en
dc.identifier.urihttp://hdl.handle.net/10919/107614en
dc.language.isoenen
dc.rightsCC0 1.0 Universal Public Domain Dedicationen
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/en
dc.subject06 Biological Sciencesen
dc.subject11 Medical and Health Sciencesen
dc.titleHerbicide injury induces DNA methylome alterations in Arabidopsisen
dc.title.serialPeerJen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherArticleen
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciencesen
pubs.organisational-group/Virginia Tech/University Research Institutesen
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Life Sciencesen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/CALS T&R Facultyen
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Life Sciences/Durelle Scotten
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/School of Plant and Environmental Sciencesen

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