Altered Germinal-Center Metabolism in B Cells in Autoimmunity
| dc.contributor.author | Shiraz, Ashton K. | en |
| dc.contributor.author | Panther, Eric J. | en |
| dc.contributor.author | Reilly, Christopher M. | en |
| dc.date.accessioned | 2022-01-11T13:49:23Z | en |
| dc.date.available | 2022-01-11T13:49:23Z | en |
| dc.date.issued | 2022-01-05 | en |
| dc.date.updated | 2022-01-10T14:38:23Z | en |
| dc.description.abstract | B lymphocytes play an important role in the pathophysiology of many autoimmune disorders by producing autoantibodies, secreting cytokines, and presenting antigens. B cells undergo extreme physiological changes as they develop and differentiate. Aberrant function in tolerogenic checkpoints and the metabolic state of B cells might be the contributing factors to the dysfunctionality of autoimmune B cells. Understanding B-cell metabolism in autoimmunity is important as it can give rise to new treatments. Recent investigations have revealed that alterations in metabolism occur in the activation of B cells. Several reports have suggested that germinal center (GC) B cells of individuals with systemic lupus erythematosus (SLE) have altered metabolic function. GCs are unique microenvironments in which the delicate and complex process of B-cell affinity maturation occurs through somatic hypermutation (SHM) and class switching recombination (CSR) and where Bcl6 tightly regulates B-cell differentiation into memory B-cells or plasma cells. GC B cells rely heavily on glucose, fatty acids, and oxidative phosphorylation (OXPHOS) for their energy requirements. However, the complicated association between GC B cells and their metabolism is still not clearly understood. Here, we review several studies of B-cell metabolism, highlighting the significant transformations that occur in GC progression, and suggest possible approaches that may be investigated to more precisely target aberrant B-cell metabolism in SLE. | en |
| dc.description.version | Published version | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.citation | Shiraz, A.K.; Panther, E.J.; Reilly, C.M. Altered Germinal-Center Metabolism in B Cells in Autoimmunity. Metabolites 2022, 12, 40. | en |
| dc.identifier.doi | https://doi.org/10.3390/metabo12010040 | en |
| dc.identifier.uri | http://hdl.handle.net/10919/107535 | en |
| dc.language.iso | en | en |
| dc.publisher | MDPI | en |
| dc.rights | Creative Commons Attribution 4.0 International | en |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en |
| dc.subject | B cells | en |
| dc.subject | germinal centers | en |
| dc.subject | BCL6 | en |
| dc.subject | lupus | en |
| dc.subject | metabolism | en |
| dc.title | Altered Germinal-Center Metabolism in B Cells in Autoimmunity | en |
| dc.title.serial | Metabolites | en |
| dc.type | Article - Refereed | en |
| dc.type.dcmitype | Text | en |