A New Method for Blood Perfusion Measurement using Non-Invasive Bio-Heat Perfusion Sensors

dc.contributor.authorRoghanizad, Ali R.en
dc.contributor.committeechairDiller, Thomas E.en
dc.contributor.committeememberVick, Brianen
dc.contributor.committeememberRobertson, John L.en
dc.contributor.departmentMechanical Engineeringen
dc.date.accessioned2017-11-10T17:59:59Zen
dc.date.available2017-11-10T17:59:59Zen
dc.date.issued2017-09-18en
dc.description.abstractThe development of a blood perfusion monitoring system capable of non-invasively providing researchers and healthcare specialists with continuous and absolute measurements of blood perfusion would be a significant improvement over the current state-of-the-art. Currently, blood perfusion measurement is primarily done qualitatively, invasively, and not in real-time. These limitations in measurement have restricted researchers and healthcare specialists from taking full advantage of the helpful information and insight measures of blood perfusion can provide. Blood perfusion measurement has many applications including, but not limited to, the transplant of organs, surgical procedures, cancer detection and treatment, prevention and treatment of pressure ulcers, diabetic neuropathy, and the monitoring of cardiovascular health. In this work, a new solution method of determining blood perfusion occurring at the surface of tissue in a real-time and quantitative manner is presented. This new method is used in conjunction with a non-invasive bio-heat perfusion sensor (CHFT+). In addition to quantitative values of blood perfusion, this new method is capable of estimating the thermal contact resistance between the tissue and bio-heat perfusion sensor as well as the core perfusing blood temperature. One of the major advantages of this new method is its ability to determine blood perfusion values regardless of the amount of thermal contact resistance present; an ability that has many applications with regard to thermal response measurement and solution methods in areas besides blood perfusion measurement. The new solution method was validated using both simulated data and experimental data. The experimental data validation was done using an established Phantom Tissue System that allows for controlled perfusion in pseudo tissue (99% porous sponge). Additionally, the experimental results were compared against the experimental results output from a different but established and accepted Mathematica based solution method. The experimental results had excellent agreement with expected values and proved the new solution method to be more accurate than methods developed and used previously.en
dc.description.abstractgeneralBlood perfusion is the local, non-directional blood flow at the capillary level. It is the blood flow at this level that facilitates the transfer of oxygen, nutrients, drugs, and waste from the arteries. This transfer, as facilitated by blood perfusion, is what gives life to tissue and organs. Consequently, blood perfusion measurement has many applications including, but not limited to, the transplant of organs, surgical procedures, cancer detection and treatment, prevention and treatment of pressure ulcers, diabetic neuropathy, and the monitoring of cardiovascular health. Currently, blood perfusion measurement is primarily done qualitatively, invasively, and not in real-time. These limitations in measurement have restricted researchers and healthcare specialists from taking full advantage of the helpful information and insight measures of blood perfusion can provide. In this work, a new method of determining blood perfusion occurring at the surface of tissue in a real-time and quantitative manner is presented. This new method is used in conjunction with a non-invasive bio-heat perfusion sensor (CHFT+). In addition to quantitative values of blood perfusion, this new method is capable of estimating the thermal contact resistance between the tissue and bio-heat perfusion sensor as well as the core perfusing blood temperature. The new solution method was validated using both simulated data and experimental data. The experimental data validation was done using an established Phantom Tissue System that allows for controlled perfusion in pseudo tissue (99% porous sponge). Additionally, the experimental results were compared against experimental results output from a different but established and accepted method. The experimental results had excellent agreement with expected values and proved the new solution method to be more accurate than methods developed and used previously.en
dc.description.degreeMaster of Scienceen
dc.format.mediumETDen
dc.identifier.urihttp://hdl.handle.net/10919/80311en
dc.language.isoenen
dc.publisherVirginia Techen
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs 3.0 United Statesen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/en
dc.subjectBlood Perfusionen
dc.subjectNon-Invasiveen
dc.subjectHeat Fluxen
dc.subjectTemperatureen
dc.subjectParameter Estimationen
dc.subjectThermal Measurementen
dc.subjectThermal Resistanceen
dc.subjectBio-instrumentationen
dc.subjectHealthcareen
dc.titleA New Method for Blood Perfusion Measurement using Non-Invasive Bio-Heat Perfusion Sensorsen
dc.typeThesisen
thesis.degree.disciplineMechanical Engineeringen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

Files

Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Roghanizad_AR_T_2017.pdf
Size:
4.29 MB
Format:
Adobe Portable Document Format
License bundle
Now showing 1 - 1 of 1
Name:
license.txt
Size:
1.5 KB
Format:
Item-specific license agreed upon to submission
Description:

Collections