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Protein kinases in Toxoplasma gondii

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dc.contributor.authorGaji, Rajshekhar Y.en
dc.contributor.authorSharp, Amanda K.en
dc.contributor.authorBrown, Anne M.en
dc.contributor.departmentBiomedical Sciences and Pathobiologyen
dc.contributor.departmentBiochemistryen
dc.contributor.departmentUniversity Librariesen
dc.date.accessioned2021-07-29T12:47:02Zen
dc.date.available2021-07-29T12:47:02Zen
dc.date.issued2021-05en
dc.description.abstractToxoplasma gondii is an obligatory intracellular pathogen that causes life threatening illness in immunodeficient individuals, miscarriage in pregnant woman, and blindness in newborn children. Similar to any other eukaryotic cell, protein kinases play critical and essential roles in the Toxoplasma life cycle. Accordingly, many studies have focused on identifying and defining the mechanism of function of these signalling proteins with a long-term goal to develop anti-Toxoplasma therapeutics. In this review, we briefly discuss classification and key components of the catalytic domain which are critical for functioning of kinases, with a focus on domains, families, and groups of kinases within Toxoplasma. More importantly, this article provides a comprehensive, current overview of research on kinase groups in Toxoplasma including the established eukaryotic AGC, CAMK, CK1, CMGC, STE, TKL families and the apicomplexan-specific FIKK, ROPK and WNG family of kinases. This work provides an overview and discusses current knowledge on Toxoplasma kinases including their localization, function, signalling network and role in acute and chronic pathogenesis, with a view towards the future in probing kinases as viable drug targets.en
dc.description.notesThe authors would like to thank Dr. Vern Carruthers for suggestions, support and critical reading of this manuscript before submission. This study was supported by a Career Development Grant from the American Heart Association, USA (18CDA34110251) to RYG.en
dc.description.sponsorshipAmerican Heart Association, USAAmerican Heart Association [18CDA34110251]en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1016/j.ijpara.2020.11.006en
dc.identifier.eissn1879-0135en
dc.identifier.issn0020-7519en
dc.identifier.issue6en
dc.identifier.pmid33581139en
dc.identifier.urihttp://hdl.handle.net/10919/104436en
dc.identifier.volume51en
dc.language.isoenen
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectApicomplexaen
dc.subjectToxoplasmaen
dc.subjectParasiteen
dc.subjectProtein kinaseen
dc.subjectPhosphorylationen
dc.titleProtein kinases in Toxoplasma gondiien
dc.title.serialInternational Journal for Parasitologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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