PSGL-1 Inhibits the Incorporation of SARS-CoV and SARS-CoV-2 Spike Glycoproteins into Pseudovirions and Impairs Pseudovirus Attachment and Infectivity

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dc.contributor.authorHe, Sijiaen
dc.contributor.authorWaheed, Abdul A.en
dc.contributor.authorHetrick, Brianen
dc.contributor.authorDabbagh, Deemahen
dc.contributor.authorAkhrymuk, Ivan V.en
dc.contributor.authorKehn-Hall, Kyleneen
dc.contributor.authorFreed, Eric O.en
dc.contributor.authorWu, Yuntaoen
dc.contributor.departmentBiomedical Sciences and Pathobiologyen
dc.date.accessioned2021-01-08T15:49:45Zen
dc.date.available2021-01-08T15:49:45Zen
dc.date.issued2020-12-30en
dc.date.updated2021-01-08T14:44:24Zen
dc.description.abstractP-selectin glycoprotein ligand-1 (PSGL-1) is a cell surface glycoprotein that binds to P-, E-, and L-selectins to mediate the tethering and rolling of immune cells on the surface of the endothelium for cell migration into inflamed tissues. PSGL-1 has been identified as an interferon-&gamma; (INF-&gamma;)-regulated factor that restricts HIV-1 infectivity, and has recently been found to possess broad-spectrum antiviral activities. Here we report that the expression of PSGL-1 in virus-producing cells impairs the incorporation of SARS-CoV and SARS-CoV-2 spike (S) glycoproteins into pseudovirions and blocks pseudovirus attachment and infection of target cells. These findings suggest that PSGL-1 may potentially inhibit coronavirus replication in PSGL-1<sup>+</sup> cellsen
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationHe, S.; Waheed, A.A.; Hetrick, B.; Dabbagh, D.; Akhrymuk, I.V.; Kehn-Hall, K.; Freed, E.O.; Wu, Y. PSGL-1 Inhibits the Incorporation of SARS-CoV and SARS-CoV-2 Spike Glycoproteins into Pseudovirions and Impairs Pseudovirus Attachment and Infectivity. Viruses 2020, 13, 46.en
dc.identifier.doihttps://doi.org/10.3390/v13010046en
dc.identifier.urihttp://hdl.handle.net/10919/101800en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectcoronavirusen
dc.subjectcellular antiviral factoren
dc.subjectpseudovirionen
dc.titlePSGL-1 Inhibits the Incorporation of SARS-CoV and SARS-CoV-2 Spike Glycoproteins into Pseudovirions and Impairs Pseudovirus Attachment and Infectivityen
dc.title.serialVirusesen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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Journal Articles, Multidisciplinary Digital Publishing Institute (MDPI)
Destination Area: Global Systems Science (GSS)
Scholarly Works, Biomedical Sciences and Pathobiology