Efficacy of short novel antimicrobial and anti-inflammatory peptides in a mouse model of methicillin-resistant Staphylococcus aureus (MRSA) skin infection

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dc.contributor.authorMohamed, Mohamed F.en
dc.contributor.authorSeleem, Mohamed N.en
dc.date.accessioned2020-09-21T16:16:38Zen
dc.date.available2020-09-21T16:16:38Zen
dc.date.issued2014-01-01en
dc.date.updated2020-09-21T16:16:36Zen
dc.description.abstractThe therapeutic efficacy of two novel short antimicrobial and anti-inflammatory peptides (RR and RRIKA) was evaluated in a mouse model of staphylococcal skin infection. RR (2%) and RRIKA (2%) significantly reduced the bacterial counts and the levels of proinflammatory cytokines, tumor necrosis factor (TNF)-α, and interleukin (IL)-6, in methicillin-resistant Staphylococcus aureus USA 300-0114 skin lesions. Furthermore, the combined therapy of RRIKA (1%) and lysostaphin (0.5%) had significantly higher antistaphylococcal and anti-inflammatory activity compared to monotherapy. This study supports the potential use of these peptides for topical treatment of methicillin-resistant Staphylococcus aureus skin infections.en
dc.description.versionPublished versionen
dc.format.extentPages 1979-1983en
dc.format.extent5 page(s)en
dc.format.mediumElectronic-eCollectionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.2147/DDDT.S72129en
dc.identifier.eissn1177-8881en
dc.identifier.issn1177-8881en
dc.identifier.orcidSeleem, Mohamed [0000-0003-0939-0458]en
dc.identifier.otherdddt-8-1979 (PII)en
dc.identifier.pmid25378910 (pubmed)en
dc.identifier.urihttp://hdl.handle.net/10919/100039en
dc.identifier.volume8en
dc.language.isoenen
dc.publisherDove Medical Pressen
dc.rightsCreative Commons Attribution-NonCommercial 3.0 Unporteden
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/en
dc.subjectLife Sciences & Biomedicineen
dc.subjectChemistry, Medicinalen
dc.subjectPharmacology & Pharmacyen
dc.subjectantimicrobial peptidesen
dc.subjectMRSAen
dc.subjectlysostaphinen
dc.subjectskin infectionen
dc.subjectmiceen
dc.subjectIN-VIVOen
dc.subjectLYSOSTAPHINen
dc.subjectINFLAMMATIONen
dc.subjectWOUNDSen
dc.subjectALPHAen
dc.subjectMRSAen
dc.subject1115 Pharmacology and Pharmaceutical Sciencesen
dc.subject.meshAnimalsen
dc.subject.meshMice, Inbred BALB Cen
dc.subject.meshMiceen
dc.subject.meshStaphylococcal Skin Infectionsen
dc.subject.meshDisease Models, Animalen
dc.subject.meshAntimicrobial Cationic Peptidesen
dc.subject.meshAnti-Inflammatory Agents, Non-Steroidalen
dc.subject.meshMicrobial Sensitivity Testsen
dc.subject.meshFemaleen
dc.subject.meshMethicillin-Resistant Staphylococcus aureusen
dc.titleEfficacy of short novel antimicrobial and anti-inflammatory peptides in a mouse model of methicillin-resistant Staphylococcus aureus (MRSA) skin infectionen
dc.title.serialDrug Design Development and Therapyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherArticleen
dc.type.otherJournalen
pubs.organisational-group/Virginia Tech/Veterinary Medicineen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Biomedical Sciences and Pathobiologyen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/CVM T&R Facultyen
pubs.organisational-group/Virginia Techen

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