Towards the development of latent heat storage electrodes for electroporation-based therapies

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dc.contributor.authorArena, Christopher B.en
dc.contributor.authorMahajan, Roop L.en
dc.contributor.authorRylander, M. Nicholeen
dc.contributor.authorDavalos, Rafael V.en
dc.contributor.departmentMechanical Engineeringen
dc.contributor.departmentInstitute for Critical Technology and Applied Scienceen
dc.contributor.departmentSchool of Biomedical Engineering and Sciencesen
dc.date.accessioned2013-07-18T14:03:33Zen
dc.date.available2013-07-18T14:03:33Zen
dc.date.issued2012-08-22en
dc.description.abstractPhase change materials (PCMs) capable of storing a large amount of heat upon transitioning from the solid-to-liquid state have been widely used in the electronics and construction industries for mitigating temperature development. Here, we show that they are also beneficial for reducing the peak tissue temperature during electroporation-based therapies. A numerical model is developed of irreversible electroporation (IRE) performed with hollow needle electrodes filled with a PCM. Results indicate that this electrode design can be utilized to achieve large ablation volumes while reducing the probability for thermal damage.en
dc.description.sponsorshipVirginia Tech Open Access Subvention Funden
dc.description.sponsorshipNSF CBET-0933335en
dc.description.sponsorshipICTAS Multi-scale Bio-Engineered Devices and Systems (MBEDS) centeren
dc.format.mimetypeapplication/pdfen
dc.identifier.citationMarissa Nichole; et al., "Towards the development of latent heat storage electrodes for electroporation-based therapies," Appl. Phys. Lett. 101, 083902 (2012); http://dx.doi.org/10.1063/1.4747332en
dc.identifier.doihttps://doi.org/10.1063/1.4747332en
dc.identifier.issn1077-3118en
dc.identifier.sourceurlhttp://scitation.aip.org/content/aip/journal/apl/101/8/10.1063/1.4747332en
dc.identifier.urihttp://hdl.handle.net/10919/23311en
dc.language.isoenen
dc.publisherAmerican Institute of Physicsen
dc.relation.ispartofseriesApplied Physics Letters;Volume 101, Issue 8en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectBiological tissuesen
dc.subjectBiomedical electrodesen
dc.subjectBiomedical materialsen
dc.subjectBiothermicsen
dc.subjectLatent heaten
dc.subjectNeedlesen
dc.subjectNumerical analysisen
dc.subjectPhase change materialsen
dc.titleTowards the development of latent heat storage electrodes for electroporation-based therapiesen
dc.title.serialApplied Physics Lettersen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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