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The Isolation of Natural Products From Plant Extracts

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dc.contributor.authorPung, Thitiyaen
dc.contributor.committeechairKingston, David G. I.en
dc.contributor.committeememberHanson, Brian E.en
dc.contributor.committeememberTanko, James M.en
dc.contributor.committeememberGandour, Richard D.en
dc.contributor.departmentChemistryen
dc.date.accessioned2014-03-14T20:41:20Zen
dc.date.adate2000-07-13en
dc.date.available2014-03-14T20:41:20Zen
dc.date.issued2000-06-28en
dc.date.rdate2001-07-13en
dc.date.sdate2000-07-12en
dc.description.abstractBioassay-guided fractionation of the ethyl acetate extract of Virola sp. (Myristicaceae) using the Sc7 yeast strain resulted in the isolation of the weakly cytotoxic biochanin A (an isoflavone compound). The bioassay of three mutant yeast strains (1138, 1104, and 1353) directed the isolation of DNA-damaging alkaloids from Solanum hostmannii. These alkaloids were identified as verazine and (20R) epimer verazine. In addition, three oxoaporphine alkaloids were isolated from the bark of Papualthia sp. (Annonaceae). Oxocrebanine and atherospermidine showed DNA-damaging activity whereas liriodenine had cytotoxic activity.en
dc.description.degreeMaster of Scienceen
dc.identifier.otheretd-07122000-16230006en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-07122000-16230006/en
dc.identifier.urihttp://hdl.handle.net/10919/33973en
dc.publisherVirginia Techen
dc.relation.haspartthesis2.pdfen
dc.relation.haspartthesis1.pdfen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectoxoaporphineen
dc.subjectverazinesen
dc.subjectnatural producten
dc.subjectbiochanin Aen
dc.subjectDNA-damaging agentsen
dc.titleThe Isolation of Natural Products From Plant Extractsen
dc.typeThesisen
thesis.degree.disciplineChemistryen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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