The involvement of IRAK-1 in the regulation of NFATc2 in T cells

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dc.contributor.authorZhang, Linen
dc.contributor.committeechairLi, Liwuen
dc.contributor.committeememberGogal, Jr., Robert M.en
dc.contributor.committeememberGood, Deborah J.en
dc.contributor.committeememberMelville, Stephen B.en
dc.contributor.departmentBiologyen
dc.date.accessioned2014-03-14T20:44:50Zen
dc.date.adate2008-10-16en
dc.date.available2014-03-14T20:44:50Zen
dc.date.issued2008-08-29en
dc.date.rdate2010-12-22en
dc.date.sdate2008-09-05en
dc.description.abstractInterleukin-1 receptor associated kinase -1 is a protein kinase pivotal in mediating signals for innate immune responses. Here, I report that IRAK-1 also regulates cell-mediated immune responses. NFATc2 (nuclear factor of activated T cells) was found to be associated with IRAK-1 in T cells in vitro and its activity was elevated in the absence of IRAK-1. In addition, IRAK-1-/- mice had increased naturally occurring regulatory T cells and inducible regulatory T cells as well as Th1 responses as compared to WT mice. The findings suggest that activated T cells might employ IRAK-1 to mediate the regulation of acquired immunity. Therefore, IRAK-1 may participate in direct signaling cross talk between the innate and the acquired immunity.en
dc.description.degreeMaster of Scienceen
dc.identifier.otheretd-09052008-130704en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-09052008-130704/en
dc.identifier.urihttp://hdl.handle.net/10919/34931en
dc.publisherVirginia Techen
dc.relation.haspartthesis101508.pdfen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectNFATc2en
dc.subjectadaptive immunityen
dc.subjectIRAK-1en
dc.subjectFoxp3en
dc.subjectsignal transductionen
dc.titleThe involvement of IRAK-1 in the regulation of NFATc2 in T cellsen
dc.typeThesisen
thesis.degree.disciplineBiologyen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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