Mathematical Modeling of the Budding Yeast Cell Cycle

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dc.contributor.authorCalzone, Laurenceen
dc.contributor.committeechairTyson, John J.en
dc.contributor.committeememberRogers, Robert C.en
dc.contributor.committeememberWheeler, Robert L.en
dc.contributor.departmentMathematicsen
dc.date.accessioned2014-03-14T20:34:28Zen
dc.date.adate2000-04-30en
dc.date.available2014-03-14T20:34:28Zen
dc.date.issued2000-04-24en
dc.date.rdate2001-04-30en
dc.date.sdate2000-04-28en
dc.description.abstractThe cell cycle of the budding yeast, Saccharomyces cerevisiae, is regulated by a complex network of chemical reactions controlling the activity of the cyclin-dependent kinases (CDKs), a family of protein kinases that drive the major events of the cell cycle. A previous mathematical model by Chen et al. (2000) described a molecular mechanism for the Start transition (passage from G1 phase to S/M phase) in budding yeast. In this thesis, my main goal is to extend Chen's model to include new information about the mechanism controlling Finish (passage from S/M phase to G1 phase). Using laws of biochemical kinetics, I transcribed the hypothetical molecular mechanism into a set of differential equations. Simulations of the wild-type cell cycle and the phenotypes of more than 60 mutants provide a thorough understanding of how budding yeast cells exit mitosis.en
dc.description.degreeMaster of Scienceen
dc.identifier.otheretd-04282000-11300054en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-04282000-11300054/en
dc.identifier.urihttp://hdl.handle.net/10919/31988en
dc.publisherVirginia Techen
dc.relation.haspartLCThesis.pdfen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectcell cycleen
dc.subjectBudding Yeasten
dc.subjectCDKen
dc.titleMathematical Modeling of the Budding Yeast Cell Cycleen
dc.typeThesisen
thesis.degree.disciplineMathematicsen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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