Impaired mentalizing in depression and the effects of borderline personality disorder on this relationship

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dc.contributor.authorRifkin-Zybutz, R. P.en
dc.contributor.authorMoran, P.en
dc.contributor.authorNolte, Tobiasen
dc.contributor.authorFeigenbaum, Janeten
dc.contributor.authorCasas, Brooksen
dc.contributor.authorFonagy, Peteren
dc.contributor.authorMontague, P. Readen
dc.contributor.departmentFralin Biomedical Research Instituteen
dc.contributor.departmentVirginia Tech Carilion School of Medicineen
dc.contributor.departmentPsychologyen
dc.date.accessioned2021-05-10T11:44:22Zen
dc.date.available2021-05-10T11:44:22Zen
dc.date.issued2021-05-04en
dc.date.updated2021-05-09T03:10:52Zen
dc.description.abstractBackground Mentalizing, the ability to understand the self and others as well as behaviour in terms of intentional mental states, is impaired in Borderline Personality Disorder (BPD). Evidence for mentalizing deficits in other mental disorders, such as depression, is less robust and these links have never been explored while accounting for the effects of BPD on mentalizing. Additionally, it is unknown whether BPD symptoms might moderate any relationship between depressive symptoms and mentalizing. Methods Using multivariate regression modelling on cross-sectional data obtained from a sample of 274 participants recruited from clinical settings, we investigated the association between mentalizing impairment and depression and examined whether this was moderated by the presence and number of concurrent BPD symptoms, while adjusting for socio-demographic confounders. Results Impaired mentalizing was associated with depressive symptoms, after adjustment for socio-demographic confounders and BPD symptoms (p = 0.002, β = − 0.18). BPD symptoms significantly moderated the association between impaired mentalizing and depressive symptoms (p = 0.003), with more severe borderline symptoms associated with a stronger effect of poor mentalization on increased depressive symptoms. Conclusion Mentalizing impairments occur in depression even after adjusting for the effect of BPD symptoms. Our findings help further characterise mentalizing impairments in depression, as well as the moderating effect of BPD symptoms on this association.. Further longitudinal work is required to investigate the direction of association.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationBorderline Personality Disorder and Emotion Dysregulation. 2021 May 04;8(1):15en
dc.identifier.doihttps://doi.org/10.1186/s40479-021-00153-xen
dc.identifier.urihttp://hdl.handle.net/10919/103231en
dc.language.isoenen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.holderThe Author(s)en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleImpaired mentalizing in depression and the effects of borderline personality disorder on this relationshipen
dc.title.serialBorderline Personality Disorder and Emotion Dysregulationen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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Journal Articles, BioMed Central and SpringerOpen
Destination Area: Adaptive Brain and Behavior (ABB)
Scholarly Works, Fralin Biomedical Research Institute at VTC
Scholarly Works, Psychology
Scholarly Works, Virginia Tech Carilion School of Medicine (VTCSOM)