Profiling nonhuman primate germline RNA to understand the legacy of early life stress

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dc.contributor.authorMorin, Elyse L.en
dc.contributor.authorGarza, Kristie M.en
dc.contributor.authorAoued, Hadjen
dc.contributor.authorSannigrahi, Somaen
dc.contributor.authorSiebert, Erin R.en
dc.contributor.authorHowell, Brittany R.en
dc.contributor.authorWalum, Hasseen
dc.contributor.authorSanchez, Mar M.en
dc.contributor.authorDias, Brian G.en
dc.date.accessioned2022-01-25T18:23:32Zen
dc.date.available2022-01-25T18:23:32Zen
dc.date.issued2021-09-09en
dc.date.updated2022-01-25T18:23:31Zen
dc.description.abstractExposure to stress is a risk factor for perturbed mental health, including impoverished regulation of emotional and physiological responses that accompany anxiety and mood disorders, substance abuse and behavioral disorders. Such disruptions to well-being could be triggered by discrete environmental events or pervasive early life stress (ELS) resulting for example from adverse caregiving. Recent data mostly collected from rodents exposed to anthropogenic stressors suggest that one way via which the detrimental effects of such stress extend beyond the exposed population to future offspring is via stress-induced alterations of RNA found in the paternal germline. In contrast, less attention has been paid to how naturally occurring stress in males might influence offspring biology and behavior. In this study, we used a translational nonhuman primate model of ELS caused by naturally occurring adverse caregiving of infant macaques to (1) profile total RNA in the adolescent male germline, and (2) identify how those RNA profiles are affected by exposure to ELS. Our findings that the top 100 transcripts identified correspond to transcripts related to germline biology and reproduction demonstrate the validity and feasibility of profiling RNA in the germline of rhesus macaques. While our small sample sizes precluded definitive assessment of stress-induced alterations of RNA in the male germline of rhesus macaques that experienced ELS, our study sets the foundation for future investigations of how early adversity might alter the male germline, across species and in experimental protocols that involve anthropogenic vs natural stressors.en
dc.description.versionPublished versionen
dc.format.extentPages 15-23en
dc.format.extent9 page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1002/jez.2501en
dc.identifier.eissn2471-5646en
dc.identifier.issn2471-5638en
dc.identifier.issue1en
dc.identifier.orcidHowell, Brittany [0000-0002-5643-2326]en
dc.identifier.pmid34498433en
dc.identifier.urihttp://hdl.handle.net/10919/107911en
dc.identifier.volume337en
dc.language.isoenen
dc.publisherWileyen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000695732300001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectLife Sciences & Biomedicineen
dc.subjectZoologyen
dc.subjectadolescenceen
dc.subjectearly life stressen
dc.subjectinfant maltreatmenten
dc.subjectnonhuman primateen
dc.subjectRNAen
dc.subjectspermen
dc.subjectGENE-REGULATIONen
dc.subjectMATERNAL-CAREen
dc.subjectINFANT ABUSEen
dc.subjectPUBLICATION BIASen
dc.subjectTRAUMA EXPOSUREen
dc.subjectRISK-FACTORSen
dc.subjectDISORDERen
dc.subjectVULNERABILITYen
dc.subjectINHERITANCEen
dc.subjectBEHAVIORen
dc.subjectRNAen
dc.titleProfiling nonhuman primate germline RNA to understand the legacy of early life stressen
dc.title.serialJournal of Experimental Zoology Part A: Ecological and Integrative Physiologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherArticleen
dc.type.otherJournalen
dcterms.dateAccepted2021-05-20en
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/University Research Institutesen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/All T&R Facultyen

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