Utilization of a Microbubble Dispersion to Increase Oxygen Transfer in Pilot-Scale Baker's Yeast Fermentation Unit

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dc.contributor.authorParakulsuksatid, Pramuken
dc.contributor.committeechairAgblevor, Foster Aryien
dc.contributor.committeememberCundiff, John S.en
dc.contributor.committeememberVelander, William H.en
dc.contributor.committeememberYousten, Allan A.en
dc.contributor.departmentBiological Systems Engineeringen
dc.date.accessioned2014-03-14T20:36:24Zen
dc.date.adate2000-05-12en
dc.date.available2014-03-14T20:36:24Zen
dc.date.issued2000-04-18en
dc.date.rdate2001-05-12en
dc.date.sdate2000-05-12en
dc.description.abstractIn the large-scale production of <i>Saccharomyces cerevisiae</i> (baker's yeast), oxygen transfer, which is one of the major limiting factors, is improved by using high agitation rates. However, high agitation rates subject the microorganisms to high shear stress and caused high power consumption. A microbubble dispersion (MBD) method was investigated to improve oxygen transfer at low agitation rates and thus reduce power consumption and shear stress on the microorganisms. The experiments were conducted at the 1-liter level and subsequently scaled-up to 50-liters using a constant volumetric oxygen transfer coefficient (<i>k<sub>L</sub>a</i>) method for scaling. In comparison to a conventional air-sparged fermentation, the MBD method considerably improved the cell mass yield, growth rate and power consumption in the 50-liter fermentor. Cell mass production in the MBD system at agitation rate of 150 rpm was about the same as those obtained for a conventional air-sparged system agitatid at 500 rpm. Power consumption in the conventional air-sparged system was three-fold that required for the same biomass yield in the MBD system. However, at the 1-liter scale, the MBD system did not show any significant advantage over the air-sparged system because of the high power consumption.en
dc.description.degreeMaster of Scienceen
dc.identifier.otheretd-05122000-00440044en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-05122000-00440044/en
dc.identifier.urihttp://hdl.handle.net/10919/32615en
dc.publisherVirginia Techen
dc.relation.haspartWholethesis.pdfen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectbaker's yeast fermentationen
dc.subjectpilot-scaleen
dc.subjectoxygen transferen
dc.subjectmicrobubble dispersionen
dc.titleUtilization of a Microbubble Dispersion to Increase Oxygen Transfer in Pilot-Scale Baker's Yeast Fermentation Uniten
dc.typeThesisen
thesis.degree.disciplineBiological Systems Engineeringen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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