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An investigation into hormonal regulation of ovine mammary gland growth during pregnancy

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dc.contributor.authorSmith, James Josephen
dc.contributor.committeechairAkers, Robert Michaelen
dc.contributor.committeememberGwazdauskas, Francis C.en
dc.contributor.committeememberBeal, Wilfred E.en
dc.contributor.committeememberWhite, John M.en
dc.contributor.departmentDairy Scienceen
dc.date.accessioned2014-03-14T21:31:33Zen
dc.date.adate2013-03-12en
dc.date.available2014-03-14T21:31:33Zen
dc.date.issued1985-05-05en
dc.date.rdate2013-03-12en
dc.date.sdate2013-03-12en
dc.description.abstractPrepartum, multiparous ewes were randomly assigned to experimental groups and sacrificed at 50(n=5), SO(n=4),115(n=5), and 140(n=4) days of gestation. Serum harvested the week prior to slaughter was assayed for progesterone (PG), prolactin (PRL) and growth hormone (GH) concentrations. Mammary tissue obtained at slaughter was assayed for receptor concentrations of progesterone (PGr), prolactin (PRLr) and insulin (Ir). Quantitative biochemical, histological and autoradiographical analyses were used to measure mammary gland growth and indicated no significant glandular growth occurs prior to 8O days of gestation. However, a major phase of parenchymal growth occurred between 8O and 115 days which coincided with significant increases in PG, PGr and PRLr concentrations. Parenchymal growth continued further into late pregnancy. GH and Ir concentrations did not change significantly during pregnancy and were not strongly correlated to growth measurements. These results suggest that mammary gland growth is receptor-mediated and direct or indirect regulation of PGr and PRLr is primarily responsible for the observed growth phenomenon.en
dc.description.degreeMaster of Scienceen
dc.format.extentviii, 112 leavesen
dc.format.mediumBTDen
dc.format.mimetypeapplication/pdfen
dc.identifier.otheretd-03122013-040148en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-03122013-040148/en
dc.identifier.urihttp://hdl.handle.net/10919/41561en
dc.language.isoenen
dc.publisherVirginia Techen
dc.relation.haspartLD5655.V855_1985.S657.pdfen
dc.relation.isformatofOCLC# 12998445en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectMammary glandsen
dc.subject.lccLD5655.V855 1985.S657en
dc.subject.lcshMammary glandsen
dc.subject.lcshSheep -- Growthen
dc.titleAn investigation into hormonal regulation of ovine mammary gland growth during pregnancyen
dc.typeThesisen
dc.type.dcmitypeTexten
thesis.degree.disciplineDairy Scienceen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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