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Effect of a non-steroidal, anti-inflammatory drug (Indocin) on selected parameters of muscular function following concentric and eccentric work

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dc.contributor.authorVejarano, Maria Eugeniaen
dc.contributor.committeechairBos, Ronald R.en
dc.contributor.committeememberHerbert, William G.en
dc.contributor.committeememberSebolt, Don R.en
dc.contributor.departmentHealth and Physical Educationen
dc.date.accessioned2014-03-14T21:49:32Zen
dc.date.adate2012-11-14en
dc.date.available2014-03-14T21:49:32Zen
dc.date.issued1985-08-05en
dc.date.rdate2012-11-14en
dc.date.sdate2012-11-14en
dc.description.abstractEvidence from various studies indicates that eccentric contractions produce more post-exercise changes in muscular function than do concentric contractions. Delayed muscular soreness, the pain and tenderness present 1 or 2 days after exercise, is negatively correlated with muscular performance and occurs particularly after eccentric work. The action of an analgesic, anti-inflammatory drug (Indocin) on muscular soreness indicates it may be effective in accelerating recovery of muscle function after eccentric work. In the study reported herein the effects of Indocin on muscular performance, as evaluated on the Cybex II isokinetic dynamometer, following prolonged concentric and eccentric work, were evaluated in 48 subjects who were randomly assigned to one of four drug groups. Subjects performed a 30 minute step test during which one limb led the stepping movement throughout (concentric contractions) and the contralateral limb trailed throughout (eccentric contractions). The muscular performance parameters of peak torque (PT), torque acceleration energy (TAE) and average power (AVP), evaluated at slow and high velocities, and the range of motion (ROM) at the knee joint were assessed prior to the step test and at five intervals thereafter. A non-significant decrease in PT and TAE at the contraction speed of 60 deg/sec were present in the eccentric limbs, greater reductions evidenced in the placebo group. Non-significant changes occurred in the concentric limbs, Non-significant changes in ROM and in muscular function parameters evaluated at 250 deg/sec were observed.en
dc.description.degreeMaster of Scienceen
dc.format.extentvi, 147 leavesen
dc.format.mediumBTDen
dc.format.mimetypeapplication/pdfen
dc.identifier.otheretd-11142012-040051en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-11142012-040051/en
dc.identifier.urihttp://hdl.handle.net/10919/45648en
dc.publisherVirginia Techen
dc.relation.haspartLD5655.V855_1985.V374.pdfen
dc.relation.isformatofOCLC# 13311152en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subject.lccLD5655.V855 1985.V374en
dc.subject.lcshExercise -- Physiological aspectsen
dc.subject.lcshMuscle contractionen
dc.subject.lcshMuscles -- Diseases -- Treatmenten
dc.subject.lcshMuscles -- Effect of drugs onen
dc.titleEffect of a non-steroidal, anti-inflammatory drug (Indocin) on selected parameters of muscular function following concentric and eccentric worken
dc.typeThesisen
dc.type.dcmitypeTexten
thesis.degree.disciplineHealth and Physical Educationen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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