Predicting drug interactions with a three level causal model

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dc.contributor.authorScheckler, Rebecca Kleinen
dc.contributor.departmentComputer Scienceen
dc.date.accessioned2014-03-14T21:34:14Zen
dc.date.adate2009-04-18en
dc.date.available2014-03-14T21:34:14Zen
dc.date.issued1990en
dc.date.rdate2009-04-18en
dc.date.sdate2009-04-18en
dc.description.abstractA medical expert system for predicting qualitative pharmacodynamic interactions of the cardiovascular system is described. TLCM traces causal paths of drug action through up to three levels of drug action. The three levels which are molecular/receptor level, physiological level and clinical level provide both deep and shallow reasoning in order to overcome the problem of unknowns in medical expert systems. Sparsity of information in pharmacology results from necessity of using non-invasive techniques for monitoring drug effects in the human subject and difficulty in isolating effect from feedback. The qualitative nature of TLCM is another attempt to deal with incomplete information in pharmacology.en
dc.description.degreeMaster of Scienceen
dc.format.extentxi, 203 leavesen
dc.format.mediumBTDen
dc.format.mimetypeapplication/pdfen
dc.identifier.otheretd-04182009-041422en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-04182009-041422/en
dc.identifier.urihttp://hdl.handle.net/10919/42156en
dc.language.isoenen
dc.publisherVirginia Techen
dc.relation.haspartLD5655.V855_1990.S333.pdfen
dc.relation.isformatofOCLC# 22336802en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subject.lccLD5655.V855 1990.S333en
dc.subject.lcshDrug interactions -- Data processingen
dc.subject.lcshInformation storage and retrieval systems -- Medicineen
dc.titlePredicting drug interactions with a three level causal modelen
dc.typeThesisen
dc.type.dcmitypeTexten
thesis.degree.disciplineComputer Scienceen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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