Widespread exposure to SARS-CoV-2 in wildlife communities

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dc.contributor.authorGoldberg, Amanda R.en
dc.contributor.authorLangwig, Kate E.en
dc.contributor.authorBrown, Katherine L.en
dc.contributor.authorMarano, Jeffrey M.en
dc.contributor.authorRai, Pallavien
dc.contributor.authorKing, Kelsie M.en
dc.contributor.authorSharp, Amanda K.en
dc.contributor.authorCeci, Alessandroen
dc.contributor.authorKailing, Christopher D.en
dc.contributor.authorKailing, Macy J.en
dc.contributor.authorBriggs, Russellen
dc.contributor.authorUrbano, Matthew G.en
dc.contributor.authorRoby, Clintonen
dc.contributor.authorBrown, Anne M.en
dc.contributor.authorWeger-Lucarelli, Jamesen
dc.contributor.authorFinkielstein, Carla V.en
dc.contributor.authorHoyt, Joseph R.en
dc.date.accessioned2024-07-30T17:21:04Zen
dc.date.available2024-07-30T17:21:04Zen
dc.date.issued2024-07-29en
dc.description.abstractPervasive SARS-CoV-2 infections in humans have led to multiple transmission events to animals. While SARS-CoV-2 has a potential broad wildlife host range, most documented infections have been in captive animals and a single wildlife species, the white-tailed deer. The full extent of SARS-CoV-2 exposure among wildlife communities and the factors that influence wildlife transmission risk remain unknown. We sampled 23 species of wildlife for SARS-CoV-2 and examined the effects of urbanization and human use on seropositivity. Here, we document positive detections of SARS-CoV-2 RNA in six species, including the deer mouse, Virginia opossum, raccoon, groundhog, Eastern cottontail, and Eastern red bat between May 2022–September 2023 across Virginia and Washington, D.C., USA. In addition, we found that sites with high human activity had three times higher seroprevalence than low human-use areas. We obtained SARS-CoV-2 genomic sequences from nine individuals of six species which were assigned to seven Pango lineages of the Omicron variant. The close match to variants circulating in humans at the time suggests at least seven recent human-to-animal transmission events. Our data support that exposure to SARS-CoV-2 has been widespread in wildlife communities and suggests that areas with high human activity may serve as points of contact for cross-species transmission.en
dc.description.sponsorshipThis project was supported by funds from NSF DEB-1911853 to K.E.L. and J.R.H., the Virginia Tech FBRI to C.V.F., One Health award from VCOM to J.W, and the American Rescue Plan Act through USDA APHIS to K.E.L, J.W., C.V.F., and J.R.H.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier6210 (Article number)en
dc.identifier.doihttps://doi.org/10.1038/s41467-024-49891-wen
dc.identifier.eissn2041-1723en
dc.identifier.issue1en
dc.identifier.orcidBrown, Katherine [0000-0002-6514-8976]en
dc.identifier.orcidFinkielstein, Carla [0000-0002-8417-4643]en
dc.identifier.orcidBrown, Anne [0000-0001-6951-8228]en
dc.identifier.orcidLangwig, Kate [0000-0001-8318-1238]en
dc.identifier.orcidHoyt, Joseph [0000-0003-0398-8264]en
dc.identifier.orcidWeger, James [0000-0002-9483-1694]en
dc.identifier.urihttps://hdl.handle.net/10919/120776en
dc.identifier.volume15en
dc.language.isoenen
dc.publisherSpringeren
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleWidespread exposure to SARS-CoV-2 in wildlife communitiesen
dc.title.serialNature Communicationsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Scienceen
pubs.organisational-group/Virginia Tech/Science/Biological Sciencesen
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