Physiological Conditions Leading to Maternal Subclinical Ketosis in Holstein Dairy Cows Can Impair the Offspring's Postnatal Growth and Gut Microbiome Development

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dc.contributor.authorHalfen, Jessicaen
dc.contributor.authorCarpinelli, Nathaly Anaen
dc.contributor.authorLasso-Ramirez, Sergioen
dc.contributor.authorMichelotti, Tainara Cristinaen
dc.contributor.authorFowler, Emily C.en
dc.contributor.authorSt-Pierre, Benoiten
dc.contributor.authorTrevisi, Erminioen
dc.contributor.authorOsorio, Johan S.en
dc.date.accessioned2023-07-28T14:48:36Zen
dc.date.available2023-07-28T14:48:36Zen
dc.date.issued2023-07-19en
dc.date.updated2023-07-28T12:22:03Zen
dc.description.abstractMaternal metabolic disruptions, such as ketosis, can have adverse effects on fetal development and influence postnatal factors. Twelve Holstein calves were randomly enrolled in this study at birth and monitored until 8 weeks of age. The study was conducted from fall 2018 until spring 2019. After completing the data collection period, calves were classified according to their respective dams ketotic condition after parturition. This classification was based on dam blood &beta;-hydroxybutyrate &lt; 1.4 mmol/L nonketotic (NONKET; n = 6 calves) or &ge;1.4 mmol/L subclinical-ketotic (SK; n = 6 calves). SK calves had greater birth body weight (<i>p</i> = 0.05) but exhibited a slower growth rate compared to NONKET calves from 1 to 8 weeks (<i>p</i> = 0.02). At birth, SK calves had lower (<i>p</i> &lt; 0.01) levels of non-esterified fatty acids and bilirubin compared to NONKET calves. Analysis of feces alpha diversity indicates that by 3 weeks, NONKET calves had greater diversity, richness, and evenness. <i>Butyricicoccus pullicaecorum</i> and <i>Gallibacterium anatis</i> were more abundant in SK calves (<i>p</i> &lt; 0.05) at 3 weeks. In contrast, NONKET calves had a greater (<i>p</i> &lt; 0.05) abundance of <i>Sharpae azabuensis</i> at 3 weeks. These findings suggest that subclinical ketosis in cows can impact the in-utero development, postnatal growth, and maturing gut microbiome of their offspring.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationHalfen, J.; Carpinelli, N.A.; Lasso-Ramirez, S.; Michelotti, T.C.; Fowler, E.C.; St-Pierre, B.; Trevisi, E.; Osorio, J.S. Physiological Conditions Leading to Maternal Subclinical Ketosis in Holstein Dairy Cows Can Impair the Offspring's Postnatal Growth and Gut Microbiome Development. Microorganisms 2023, 11, 1839.en
dc.identifier.doihttps://doi.org/10.3390/microorganisms11071839en
dc.identifier.urihttp://hdl.handle.net/10919/115928en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectcalvesen
dc.subjectketosisen
dc.subjectgut microbiomeen
dc.subject16S rRNAen
dc.subjectbacterial compositionen
dc.titlePhysiological Conditions Leading to Maternal Subclinical Ketosis in Holstein Dairy Cows Can Impair the Offspring's Postnatal Growth and Gut Microbiome Developmenten
dc.title.serialMicroorganismsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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