Metalloporphyrins as Tools for Deciphering the Role of Heme Oxygenase in Renal Immune Injury

dc.contributor.authorLianos, Elias A.en
dc.contributor.authorDetsika, Maria G.en
dc.date.accessioned2023-04-12T16:26:43Zen
dc.date.available2023-04-12T16:26:43Zen
dc.date.issued2023-04-06en
dc.date.updated2023-04-12T13:24:17Zen
dc.description.abstractRenal immune injury is a frequent cause of end-stage renal disease, and, despite the progress made in understanding underlying pathogenetic mechanisms, current treatments to preserve renal function continue to be based mainly on systemic immunosuppression. Small molecules, naturally occurring biologic agents, show considerable promise in acting as disease modifiers and may provide novel therapeutic leads. Certain naturally occurring or synthetic Metalloporphyrins (Mps) can act as disease modifiers by increasing heme oxygenase (HO) enzymatic activity and/or synthesis of the inducible HO isoform (HO-1). Depending on the metal moiety of the Mp employed, these effects may occur in tandem or can be discordant (increased HO-1 synthesis but inhibition of enzyme activity). This review discusses effects of Mps, with varying redox-active transitional metals and cyclic porphyrin cores, on mechanisms underlying pathogenesis and outcomes of renal immune injury.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationLianos, E.A.; Detsika, M.G. Metalloporphyrins as Tools for Deciphering the Role of Heme Oxygenase in Renal Immune Injury. Int. J. Mol. Sci. 2023, 24, 6815.en
dc.identifier.doihttps://doi.org/10.3390/ijms24076815en
dc.identifier.urihttp://hdl.handle.net/10919/114484en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectheme oxygenaseen
dc.subjectimmune mediateden
dc.subjectrenal injuryen
dc.titleMetalloporphyrins as Tools for Deciphering the Role of Heme Oxygenase in Renal Immune Injuryen
dc.title.serialInternational Journal of Molecular Scienceen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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