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Dietary Supplementation of Baicalein Affects Gene Expression in Broiler Adipose Tissue During the First Week Post-hatch

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dc.contributor.authorXiao, Yangen
dc.contributor.authorHalter, Baileyen
dc.contributor.authorBoyer, Caseyen
dc.contributor.authorCline, Mark A.en
dc.contributor.authorLiu, Dongminen
dc.contributor.authorGilbert, Elizabeth R.en
dc.date.accessioned2021-09-02T17:44:46Zen
dc.date.available2021-09-02T17:44:46Zen
dc.date.issued2021-06-25en
dc.description.abstractDietary supplementation of baicalein, a flavonoid, has anti-obesity effects in mammals and broiler chickens. The aim of this study was to determine the effect of dietary baicalein supplementation on broiler growth and adipose tissue and breast muscle deposition. Fifty Hubbard Cobb-500 day-of-hatch broiler chicks were assigned to a control starter diet or control diet supplemented with 125, 250, or 500 mg/kg baicalein and diets were fed for the first 6 days post-hatch. Body weight, average daily body weight gain, and average daily food intake were all reduced by 500 mg/kg baicalein. Breast muscle and subcutaneous and abdominal fat weights were also reduced in chicks that consumed the baicalein-supplemented diets. mRNAs for genes encoding factors involved in adipogenesis and fat storage, 1-acylglycerol-3-phosphate-O-acyltransferase 2, CCAAT/enhancer-binding protein b, perilipin-1, and sterol regulatory element-binding transcription factor 1, were more highly expressed in the adipose tissue of broilers supplemented with baicalein than the controls, independent of depot. Diacylglycerol acyltransferase and peroxisome proliferator-activated receptor gamma mRNAs, involved in triacylglycerol synthesis and adipogenesis, respectively, were greater in subcutaneous than abdominal fat, which may contribute to differences in expansion rates of these depots. Results demonstrate effects of dietary supplementation of baicalein on growth performance in broilers during the early post-hatch stage and molecular effects in major adipose tissue depots. The mild reduction in food intake coupled to slowed rate of breast muscle and adipose tissue accumulation may serve as a strategy to modulate broiler growth and body composition to prevent metabolic and skeletal disorders later in life.en
dc.description.sponsorshipFunding for this work was provided in part by the John Lee Pratt Endowment at Virginia Tech, the Virginia Agricultural Experiment Station and the Hatch Program of the National Institute of Food and Agriculture, U.S. Department of Agriculture.en
dc.description.versionPublished versionen
dc.format.extent8 pagesen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationXiao Y, Halter B, Boyer C, Cline MA, Liu D and Gilbert ER (2021) Dietary Supplementation of Baicalein Affects Gene Expression in Broiler Adipose Tissue During the First Week Post-hatch. Front. Physiol. 12:697384. doi: 10.3389/fphys.2021.697384en
dc.identifier.doihttps://doi.org/10.3389/fphys.2021.697384en
dc.identifier.urihttp://hdl.handle.net/10919/104914en
dc.identifier.volume12en
dc.language.isoenen
dc.publisherFrontiersen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectflavonoiden
dc.subjectbaicaleinen
dc.subjectchickenen
dc.subjectadipose tissueen
dc.subjectbreast muscleen
dc.titleDietary Supplementation of Baicalein Affects Gene Expression in Broiler Adipose Tissue During the First Week Post-hatchen
dc.title.serialFrontiers in Physiologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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