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Leaky Gut As a Danger Signal for Autoimmune Diseases

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dc.contributor.authorMu, Q.en
dc.contributor.authorKirby, J.en
dc.contributor.authorReilly, Christopher M.en
dc.contributor.authorLuo, Xin M.en
dc.date.accessioned2017-06-25T12:40:37Zen
dc.date.available2017-06-25T12:40:37Zen
dc.date.issued2017-05-23en
dc.description.abstractThe intestinal epithelial lining, together with factors secreted from it, forms a barrier that separates the host from the environment. In pathologic conditions, the permeability of the epithelial lining may be compromised allowing the passage of toxins, antigens, and bacteria in the lumen to enter the blood stream creating a “leaky gut.” In individuals with a genetic predisposition, a leaky gut may allow environmental factors to enter the body and trigger the initiation and development of autoimmune disease. Growing evidence shows that the gut microbiota is important in supporting the epithelial barrier and therefore plays a key role in the regulation of environmental factors that enter the body. Several recent reports have shown that probiotics can reverse the leaky gut by enhancing the production of tight junction proteins; however, additional and longer term studies are still required. Conversely, pathogenic bacteria that can facilitate a leaky gut and induce autoimmune symptoms can be ameliorated with the use of antibiotic treatment. Therefore, it is hypothesized that modulating the gut microbiota can serve as a potential method for regulating intestinal permeability and may help to alter the course of autoimmune diseases in susceptible individuals.en
dc.description.versionPublished versionen
dc.format.extent? - ? (10) page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3389/fimmu.2017.00598en
dc.identifier.issn1664-3224en
dc.identifier.orcidLuo, XM [0000-0002-2809-5836]en
dc.identifier.urihttp://hdl.handle.net/10919/78256en
dc.identifier.volume8en
dc.language.isoenen
dc.publisherFrontiersen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000401873100001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectImmunologyen
dc.subjectleaky guten
dc.subjectmicrobial translocationen
dc.subjectgut microbiotaen
dc.subjectprobioticsen
dc.subjectautoimmunityen
dc.subjectSYSTEMIC-LUPUS-ERYTHEMATOSUSen
dc.subjectINCREASED INTESTINAL PERMEABILITYen
dc.subjectINDUCED LIVER-INJURYen
dc.subjectLIGHT-CHAIN KINASEen
dc.subjectPRISTANE-INDUCED LUPUSen
dc.subjectCOLONIC MUCUS BARRIERen
dc.subjectVITAMIN-D-RECEPTORen
dc.subjectGOBLET CELLSen
dc.subjectMUCOSAL BARRIERen
dc.subjectEPITHELIAL-CELLSen
dc.titleLeaky Gut As a Danger Signal for Autoimmune Diseasesen
dc.title.serialFrontiers in Immunologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/Veterinary Medicineen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Biomedical Sciences and Pathobiologyen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/CVM T&R Facultyen

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