Evaluation of conditions for quantitative recovery of a drug from animal feed using supercritical fluid CO₂ extraction

dc.contributor.authorMesser, Dale C.en
dc.contributor.committeechairTaylor, Larry T.en
dc.contributor.committeememberMarand, Hervé L.en
dc.contributor.committeememberAnderson, Mark R.en
dc.contributor.departmentChemistryen
dc.date.accessioned2014-03-14T21:43:55Zen
dc.date.adate2003-08-28en
dc.date.available2014-03-14T21:43:55Zen
dc.date.issued1991en
dc.date.rdate2003-08-28en
dc.date.sdate2003-08-28en
dc.description.abstractSupercritical fluid extraction (SFE) continues to be explored as a feasible alternative to traditional Soxhlet and other types of extraction. In many cases SFE is cleaner, faster, and less expensive than the traditional types of extractions. This investigation has focused on the evaluation of Supercritical CO₂ extraction as a quantitative method for recovery of a hypolipidemic drug (tradename xenalipin) from an animal feed matrix. Initial emphasis of this study focused on the recovery of xenalipin from a the animal feed matrix employing a liquid solvent trap. By studying the effect of time of extraction versus recovery of drug, the liquid trap was shown to be inadequate. Further studies implemented the extraction of xenalipin from a filter paper matrix and the use of solid phase traps. This method of inquiry was use to evaluate the degree of recovery as related to the parameters of CO₂ density, extraction time, and flow rates of CO₂. After achieving quantitative extraction of xenalipin from filter these parameters were transferred to the animal feed matrix. The animal feed matrix was prepared using three different methods. Each matrix was evaluated for homogeneity of sample and ability to achieve quantitative extraction.en
dc.description.degreeMaster of Scienceen
dc.format.extentvii, 62 leavesen
dc.format.mediumBTDen
dc.format.mimetypeapplication/pdfen
dc.identifier.otheretd-08282003-155315en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-08282003-155315/en
dc.identifier.urihttp://hdl.handle.net/10919/44463en
dc.language.isoenen
dc.publisherVirginia Techen
dc.relation.haspartmesser.pdfen
dc.relation.isformatofOCLC# 24425078en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subject.lccLD5655.V855 1991.M488en
dc.subject.lcshSupercritical fluid extraction -- Researchen
dc.titleEvaluation of conditions for quantitative recovery of a drug from animal feed using supercritical fluid CO₂ extractionen
dc.typeThesisen
dc.type.dcmitypeTexten
thesis.degree.disciplineChemistryen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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