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Pediatric diffuse hemispheric glioma H3 G34-mutant with gains of the BRAF locus: An illustrative case

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dc.contributor.authorMarlow, Christineen
dc.contributor.authorCuoco, Joshua A.en
dc.contributor.authorHoggarth, Austin R.en
dc.contributor.authorStump, Michael S.en
dc.contributor.authorApfel, Lisa S.en
dc.contributor.authorRogers, Cara M.en
dc.date.accessioned2023-09-28T14:47:16Zen
dc.date.available2023-09-28T14:47:16Zen
dc.date.issued2023-03en
dc.date.updated2023-09-27T20:00:59Zen
dc.description.abstractDiffuse hemispheric glioma, H3 G34-mutant, is a recently recognized distinct high-grade glioma with a dismal prognosis. In addition to the H3 G34 missense mutation, numerous genetic events have been identified in these malignant tumors, including ATRX, TP53, and, rarely, BRAF genes. There are only a few reports to date that have identified BRAF mutations in diffuse hemispheric glioma, H3 G34-mutant. Moreover, to our knowledge, gains of the BRAF locus have yet to be described. Here, we present a case of an 11-year-old male with a diffuse hemispheric glioma, H3 G34-mutant, found to have novel gains of the BRAF locus. Furthermore, we emphasize the current genetic landscape of diffuse hemispheric glioma, H3 G34-mutant, and implications of an aberrant BRAF signaling pathway.en
dc.description.versionPublished versionen
dc.format.extent7 page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifierARTN 20363613231168704 (Article number)en
dc.identifier.doihttps://doi.org/10.1177/20363613231168704en
dc.identifier.eissn2036-3613en
dc.identifier.issn2036-3605en
dc.identifier.otherPMC10088409en
dc.identifier.other10.1177_20363613231168704 (PII)en
dc.identifier.pmid37056711en
dc.identifier.urihttp://hdl.handle.net/10919/116366en
dc.identifier.volume15en
dc.language.isoenen
dc.publisherSAGEen
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pubmed/37056711en
dc.rightsCreative Commons Attribution-NonCommercial 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/en
dc.subjectOncologyen
dc.subjectDiffuse hemispheric gliomaen
dc.subjectH3 G34-mutanten
dc.subjectH3 K27-mutanten
dc.subjectneuro-oncologyen
dc.subjectpediatricen
dc.subjectACTIVATIONen
dc.subject31 Biological Sciencesen
dc.subject32 Biomedical and Clinical Sciencesen
dc.subject3105 Geneticsen
dc.subject3211 Oncology and Carcinogenesisen
dc.subjectBrain Disordersen
dc.subjectRare Diseasesen
dc.subjectNeurosciencesen
dc.subjectBrain Canceren
dc.subjectGeneticsen
dc.subjectCanceren
dc.titlePediatric diffuse hemispheric glioma H3 G34-mutant with gains of the BRAF locus: An illustrative caseen
dc.title.serialRare Tumorsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherArticleen
dc.type.otherJournalen
dcterms.dateAccepted2023-03-22en
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicineen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/Surgeryen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/Basic Scienceen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/Basic Science/Basic Scienceen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/Surgery/General Surgeryen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/Surgery/Neurosurgeryen

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