Correlation of Homocysteine Concentration with Plasma Fibrinogen and Physical Activity in Males with Coronary Artery Disease

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dc.contributor.authorPrerost, Monica R.en
dc.contributor.committeecochairHerbert, William G.en
dc.contributor.committeecochairFeldman, Bernard F.en
dc.contributor.committeememberSouthard, Douglas R.en
dc.contributor.committeememberJamison, Scott E.en
dc.contributor.departmentHuman Nutrition, Foods, and Exerciseen
dc.date.accessioned2014-03-14T20:51:38Zen
dc.date.adate1997-05-06en
dc.date.available2014-03-14T20:51:38Zen
dc.date.issued1997-06-05en
dc.date.rdate1997-05-06en
dc.date.sdate1998-07-26en
dc.description.abstractElevated homocysteine (Hcy) concentration has been identified as an independent risk factor for premature CAD. Associations between Hcy concentrations and established cardiovascular risk factors have occasionally, but not consistently, been demonstrated. Plasma fibrinogen and total Hcy concentrations, along with other risk factors, folate and Bvitamin supplements, and medications, were recorded for 40 males (mean age ± SD: 65 ± 9.8 yr) with CAD. Physical activity was assessed using the Modifiable Activity Questionnaire (MAQ), a written questionnaire which appraises leisure and occupational activities by recall for a 12 month period. Univariate analyses revealed those subjects on beta-blocker therapy (n = 12) had lower fibrinogen concentrations than those not on these medications (n = 28) (277.7 ± 16.7 vs. 316.1 ± 10.9 mg/dl , respectively, p = 0.04). A trend existed for those on beta-blockade to also have lower Hcy concentrations (8.3 ± 0.66 vs 9.7 ± 0.43 µmol/L, respectively, p = 0.058). Subjects in the upper tertile of physical activity had significantly lower fibrinogen concentrations than those in the lower tertile (274.7 ± 38 mg/dl vs. 320.2 ± 63, respectively, p = 0.05). Homocysteine concentration was found to be positively associated with age (p = 0.0008). No significant associations were established with multivariate analyses among fibrinogen, Hcy, physical activity, age, BMI, B-vitamin and folate supplements, beta-blocker therapy, total cholesterol, HDL, LDL, triglycerides, and TC/HDL ratio. These results support the hypothesis that hyperhomocysteinemia is an independent risk factor for CAD. Future studies should consider the favorable effects of beta-blockade, which may be a confounding factor, on Hcy and fibrinogen concentrations. Knowledge of associations may contribute toward understanding of the pathogenesis of CAD.en
dc.description.degreeMaster of Scienceen
dc.identifier.otheretd-474822559741551en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-474822559741551/en
dc.identifier.urihttp://hdl.handle.net/10919/36739en
dc.publisherVirginia Techen
dc.relation.haspartfinal.pdfen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjecthomocysteineen
dc.subjectcoronary artery diseaseen
dc.titleCorrelation of Homocysteine Concentration with Plasma Fibrinogen and Physical Activity in Males with Coronary Artery Diseaseen
dc.typeThesisen
thesis.degree.disciplineHuman Nutrition, Foods, and Exerciseen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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