Human Breast Milk 3’-Sialyllactose Positively Associates with Language Development During Infancy

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dc.contributor.authorCho, Seoyoonen
dc.contributor.authorZhu, Ziliangen
dc.contributor.authorLi, Tengfeien
dc.contributor.authorBaluyot, Kristineen
dc.contributor.authorHowell, Brittany R.en
dc.contributor.authorHazlett, Heatheren
dc.contributor.authorElison, Jeden
dc.contributor.authorHauser, Jonasen
dc.contributor.authorSprenger, Norberten
dc.contributor.authorWu, Dien
dc.contributor.authorLin, Weilien
dc.date.accessioned2022-01-25T18:24:58Zen
dc.date.available2022-01-25T18:24:58Zen
dc.date.issued2021en
dc.date.updated2022-01-25T18:24:56Zen
dc.description.abstractBackground: Genetic polymorphisms leading to variations in human milk oligosaccharide (HMO) composition have been reported. Alpha-Tetrasaccharide (A-tetra), an HMO, has been shown to only be present (>limit of detection; A-tetra+) in the human milk (HM) of women with blood type A, suggesting genetic origins determining the presence or absence (A-tetra-) of A-tetra in HM. Objectives: This study aimed to determine whether associations exist between HMO concentrations and cognitive development, and whether the associations vary between A-tetra+ and A-tetra- groups in children (<25 months old). Methods: We enrolled typically developing children (2–25 months old; mean, 10 months old) who were at least partially breastfed at the study visit. The Mullen Scales of Early Learning (MSEL) were used as the primary outcome measure to assess early cognitive development. Linear mixed effects models were employed by stratifying children based on A-tetra levels (A-tetra+ or A-tetra- ) to assess associations between age-removed HMO concentrations and both MSEL composite scores and the 5 subdomain scores. Results: A total of 99 mother-child dyads and 183HMsamples were included (A-tetra+: 57 samples, 33 dyads; A-tetra-: 126 samples, 66 dyads). No significant association was observed between HMOs and MSEL when all samples were analyzed together. The composite score and 3’-sialyllactose (3’-SL) levels were positively associated [P = 0.002; effect size (EF), 13.12; 95% CI, 5.36–20.80] in the Atetra + group. This association was driven by the receptive (adjusted P = 0.015; EF, 9.95; 95% CI, 3.91–15.99) and expressive (adjusted P = 0.048; EF, 7.53; 95% CI, 2.51–13.79) language subdomain scores. Furthermore, there was an interaction between 3’-SL and age for receptive language (adjusted P = 0.03; EF, -14.93; 95% CI, - 25.29 to -4.24). Conclusions: Our study reports the association of 3’-SL and cognition, particularly language functions, in typically developing children who received HM containing detectable A-tetra during infancy.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.orcidHowell, Brittany [0000-0002-5643-2326]en
dc.identifier.urihttp://hdl.handle.net/10919/107912en
dc.language.isoenen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subject09 Engineeringen
dc.subject11 Medical and Health Sciencesen
dc.subjectNutrition & Dieteticsen
dc.titleHuman Breast Milk 3’-Sialyllactose Positively Associates with Language Development During Infancyen
dc.title.serialAmerican Journal of Clinical Nutritionen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherArticleen
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/University Research Institutesen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/All T&R Facultyen

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