Effects of dairy products on intestinal integrity in heat-stressed pigs.

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dc.contributor.authorSanz Fernandez, M. Victoriaen
dc.contributor.authorPearce, Sarah C.en
dc.contributor.authorMani, Venkateshen
dc.contributor.authorGabler, Nicholas K.en
dc.contributor.authorMetzger, Lloyden
dc.contributor.authorPatience, John F.en
dc.contributor.authorRhoads, Robert P.en
dc.contributor.authorBaumgard, Lance H.en
dc.contributor.departmentAnimal and Poultry Sciencesen
dc.date.accessioned2017-01-12T20:15:35Zen
dc.date.available2017-01-12T20:15:35Zen
dc.date.issued2014-07en
dc.description.abstractHeat stress compromises intestinal integrity which may partially explain its negative effects on animal health and productivity. Research suggests that challenged intestinal barrier function improves with dietary dairy products in various models. Thus, the study objective was to evaluate the effects of bovine milk whey protein (WP) and colostral whey protein (CWP) on intestinal integrity in heat-stressed pigs. Crossbred gilts (39 ± 3 kg body weight) were fed 1 of 4 diets (n = 8 pigs/diet): control (Ct), control diet containing an 80% WP and 20% CWP product (WP80), control diet containing a 98% WP and 2% CWP product (WP98), and control diet containing a 100% WP product (WP100). After 7d on experimental diets, pigs were exposed to constant heat stress conditions (32 °C) for 24h. There were no treatment differences in growth or body temperature indices prior to heat stress. During heat exposure, both rectal temperature and respiration rate increased (+0.85 °C and 3-fold, respectively; P < 0.01), and feed intake and body weight decreased (44% and -0.5kg, respectively; P < 0.01), but neither variable was affected by dietary treatments. Plasma L-lactate and D-lactate concentrations increased (36%; P < 0.01) and tended to increase (19%; P = 0.09) with heat stress. After 24h of heat exposure, WP100-fed pigs had lower plasma D-lactate relative to Ct-fed pigs. Ileal transepithelial electrical resistance was decreased (37%; P = 0.02) in WP80 pigs, compared with controls. No differences were detected in other intestinal integrity ex vivo measurements. These data demonstrate that dietary WP and CWP did not mitigate intestinal integrity dysfunction during severe heat stress.en
dc.description.versionPublished versionen
dc.format.extent128 - 134 page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.4161/temp.29561en
dc.identifier.issn2332-8940en
dc.identifier.issue2en
dc.identifier.urihttp://hdl.handle.net/10919/74287en
dc.identifier.volume1en
dc.language.isoenen
dc.relation.urihttp://www.ncbi.nlm.nih.gov/pubmed/27583294en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectdairy productsen
dc.subjectheat stressen
dc.subjectintestinal integrityen
dc.subjectpigsen
dc.titleEffects of dairy products on intestinal integrity in heat-stressed pigs.en
dc.title.serialTemperature (Austin)en
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciencesen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/Animal and Poultry Sciencesen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/CALS T&R Facultyen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen

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