Role of bacille Calmette-Guérin in preventing tuberculous infection

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dc.contributor.authorAdinarayanan, S.en
dc.contributor.authorCulp, Rachel K.en
dc.contributor.authorSubramani, R.en
dc.contributor.authorAbbas, Kaja M.en
dc.contributor.authorRadhakrishna, S.en
dc.contributor.authorSwaminathan, S.en
dc.coverage.countryFranceen
dc.date.accessioned2017-04-14T01:54:53Zen
dc.date.available2017-04-14T01:54:53Zen
dc.date.issued2017-04-01en
dc.description.abstractSETTING: Rural community in South India. OBJECTIVE: To determine the role of bacille Calmette-Guérin (BCG) in preventing tuberculous infection in children. DESIGN: A prevalence survey was undertaken in 1999-2001 in a representative rural population in Tiruvallur District in South India using cluster sampling. Tuberculin testing was performed among all children aged <15 years, and all adults aged 15 years were questioned about chest symptoms and underwent radiography, followed by sputum examinations, if indicated. RESULTS: In children living in households with a tuberculosis case, the proportion with evidence of tuberculous infection was 35.5% of 200 in the absence of a BCG scar and 27.0% of 100 in its presence, a reduction of 24% (P = 0.14). In very young children (age <5 years), the corresponding proportions were 29.1% of 55 and 11.9% of 42, a reduction of 59%; the difference was statistically significant (P = 0.048). CONCLUSION: There is a possible role for BCG in preventing tuberculous infection in very young children.en
dc.description.versionPublished versionen
dc.format.extent420 - 424 page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.5588/ijtld.16.0833en
dc.identifier.eissn1815-7920en
dc.identifier.issue4en
dc.identifier.orcidAbbas, KM [0000-0003-0563-1576]en
dc.identifier.urihttp://hdl.handle.net/10919/77405en
dc.identifier.volume21en
dc.language.isoenen
dc.relation.urihttp://www.ncbi.nlm.nih.gov/pubmed/28284257en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.titleRole of bacille Calmette-Guérin in preventing tuberculous infectionen
dc.title.serialInternational Journal of Tuberculosis and Lung Diseaseen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/Veterinary Medicineen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/CVM T&R Facultyen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Population Health Sciencesen

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