The Effects of Dha Supplementation on Markers of Inflammation and Muscle Damage Following an Acute Eccentric Exercise Bout

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dc.contributor.authorDiLorenzo, Frank Michaelen
dc.contributor.committeechairRankin, Janet L. Walbergen
dc.contributor.committeememberGrange, Robert W.en
dc.contributor.committeememberNewton, William E.en
dc.contributor.departmentHuman Nutrition, Foods, and Exerciseen
dc.date.accessioned2014-03-14T21:40:34Zen
dc.date.adate2012-08-15en
dc.date.available2014-03-14T21:40:34Zen
dc.date.issued2012-07-09en
dc.date.rdate2012-08-15en
dc.date.sdate2012-07-19en
dc.description.abstractAim: The purpose of this study was to investigate the influence of docosahexaenoic acid (DHA) on muscle damage and inflammation following an acute eccentric exercise bout. Methods: A double-blind placebo-controlled, study was performed using 41 healthy, untrained males aged 18-28 y who consumed either 2 g/d DHA or placebo (PL, corn oil) for 32 days. Supplements were consumed for 28 days prior to exercise. Participants completed an eccentric exercise procedure of the elbow flexors at 140% of 1-RM (6 sets x 10 repetitions). The time under tension (TUT) for each set of eccentric contractions was recorded manually from the investigators voice commands. Fasted blood samples for prostaglandin E2 (PGE2), interleukin-6 (IL-6), interleukin-1 receptor antagonist (IL1-ra), C-reactive protein and creatine kinase (CK) were assessed on days 1, 2 and 4. Fasted serum DHA was measured at baseline (day -28) and on day 1. Peak isometric strength of the elbow flexors, delayed-onset muscle soreness, and range of motion were measured on day 1 prior to exercise and days 2, 3, and 4 following exercise. Results: DHA significantly reduced natural log of CK (p<0.05) response over 4 d. Additionally, IL-6 area under the curve (AUC) was reduced for DHA compared to PL (3.6 ± 2.5 pg/mL vs. 5.3 ± 2.7 pg/mL) (p<0.05). TUT/set was higher in the DHA group compared to placebo (p<0.05). There were no other significant differences between treatments. Conclusion: DHA supplementation produced lower indicators of muscle damage (CK) and inflammation (IL-6 AUC). DHA supplementation resulted in greater TUT/set.en
dc.description.degreeMaster of Scienceen
dc.identifier.otheretd-07192012-115704en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-07192012-115704/en
dc.identifier.urihttp://hdl.handle.net/10919/43760en
dc.publisherVirginia Techen
dc.relation.haspartDiLorenzo_FM_T_2012.pdfen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectIL-6en
dc.subjectDOMSen
dc.subjectDHAen
dc.subjectCreatine Kinaseen
dc.titleThe Effects of Dha Supplementation on Markers of Inflammation and Muscle Damage Following an Acute Eccentric Exercise Bouten
dc.typeThesisen
thesis.degree.disciplineHuman Nutrition, Foods, and Exerciseen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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