Effect of chronic vapor nicotine exposure on affective and cognitive behavior in male mice

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dc.contributor.authorMurdaugh, Laura B.en
dc.contributor.authorMiliano, Cristinaen
dc.contributor.authorChen, Ireneen
dc.contributor.authorFaunce, Christine L.en
dc.contributor.authorNatividad, Luis A.en
dc.contributor.authorGregus, Ann M.en
dc.contributor.authorBuczynski, Matthew W.en
dc.date.accessioned2025-02-18T12:57:15Zen
dc.date.available2025-02-18T12:57:15Zen
dc.date.issued2024-03-19en
dc.description.abstractNicotine use is a leading cause of preventable deaths worldwide, and most of those who attempt to quit will relapse. While electronic cigarettes and other electronic nicotine delivery systems (ENDS) were presented as a safer alternative to traditional cigarettes and promoted as devices to help traditional tobacco smokers reduce or quit smoking, they have instead contributed to increasing nicotine use among youths. Despite this, ENDS also represent a useful tool to create novel preclinical animal models of nicotine exposure that more accurately represent human nicotine use. In this study, we validated a chronic, intermittent, ENDS-based passive vapor exposure model in mice, and then measured changes in multiple behaviors related to nicotine abstinence. First, we performed a behavioral dose curve to investigate the effects of different nicotine inter-vape intervals on various measures including body weight, locomotor activity, and pain hypersensitivity. Next, we performed a pharmacokinetic study to measure plasma levels of nicotine and cotinine following chronic exposure for each inter-vape interval. Finally, we utilized a behavior test battery at a single dosing regimen that produces blood levels equivalent to human smokers in order to characterize the effects of chronic nicotine, vehicle, or passive airflow and identified nicotine-induced impairments in cognitive behavior.en
dc.description.versionPublished versionen
dc.format.extent13 page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifierARTN 6646 (Article number)en
dc.identifier.doihttps://doi.org/10.1038/s41598-024-56766-zen
dc.identifier.eissn2045-2322en
dc.identifier.issn2045-2322en
dc.identifier.issue1en
dc.identifier.orcidBuczynski, Matthew [0000-0001-5931-7107]en
dc.identifier.other10.1038/s41598-024-56766-z (PII)en
dc.identifier.pmid38503831en
dc.identifier.urihttps://hdl.handle.net/10919/124612en
dc.identifier.volume14en
dc.language.isoenen
dc.publisherNature Portfolioen
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pubmed/38503831en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectENDSen
dc.subjecte-cigaretteen
dc.subjectNicotineen
dc.subjectVapingen
dc.subjectCognitiveen
dc.subjectAddictionen
dc.subject.meshAnimalsen
dc.subject.meshHumansen
dc.subject.meshMiceen
dc.subject.meshGasesen
dc.subject.meshNicotineen
dc.subject.meshCotinineen
dc.subject.meshSmokingen
dc.subject.meshCognitionen
dc.subject.meshAdolescenten
dc.subject.meshMaleen
dc.subject.meshElectronic Nicotine Delivery Systemsen
dc.titleEffect of chronic vapor nicotine exposure on affective and cognitive behavior in male miceen
dc.title.serialScientific Reportsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherArticleen
dc.type.otherJournalen
dcterms.dateAccepted2024-03-11en
pubs.organisational-groupVirginia Techen
pubs.organisational-groupVirginia Tech/Scienceen
pubs.organisational-groupVirginia Tech/Faculty of Health Sciencesen
pubs.organisational-groupVirginia Tech/All T&R Facultyen
pubs.organisational-groupVirginia Tech/Science/COS T&R Facultyen
pubs.organisational-groupVirginia Tech/Science/School of Neuroscienceen

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